中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
6期
20-22
,共3页
手足口病%抗体%肠道病毒71型,人%柯萨奇病毒A16型
手足口病%抗體%腸道病毒71型,人%柯薩奇病毒A16型
수족구병%항체%장도병독71형,인%가살기병독A16형
Hand,foot and mouth disease%Antibody%Enterovirus 71,human%Coxsackie virus A16
目的 探讨肠道病毒71型(EV71)和柯萨奇病毒A16型(CA16)抗体筛查在手足口病中的应用及相关性.方法 采用酶联免疫吸附法对确诊的281例手足口病患儿进行血清EV71-IgM抗体和CA16-IgM抗体检测.结果 EV71-IgM抗体阳性144例(51.2％,144/281),CA16-IgM抗体阳性90例(32.0％,90/281),EV71-IgM和CA16-IgM双阳性17例(6.0％,17/281),即抗体阳性确切例数为217例,抗体阳性率为77.2％(217/281).EV71-IgM抗体阳性率与CA16-IgM抗体阳性率比较差异有统计学意义(x2=21.35,P＜0.01),总体男性与女性抗体阳性率[95.1％(135/142)比71.2％(99/139)]比较差异有统计学意义(x2=8.22,P＜0.01).结论 早期进行EV71-IgM和CA16-IgM抗体联合检测,对临床诊断手足口病及监控治疗具有重要意义.
目的 探討腸道病毒71型(EV71)和柯薩奇病毒A16型(CA16)抗體篩查在手足口病中的應用及相關性.方法 採用酶聯免疫吸附法對確診的281例手足口病患兒進行血清EV71-IgM抗體和CA16-IgM抗體檢測.結果 EV71-IgM抗體暘性144例(51.2％,144/281),CA16-IgM抗體暘性90例(32.0％,90/281),EV71-IgM和CA16-IgM雙暘性17例(6.0％,17/281),即抗體暘性確切例數為217例,抗體暘性率為77.2％(217/281).EV71-IgM抗體暘性率與CA16-IgM抗體暘性率比較差異有統計學意義(x2=21.35,P＜0.01),總體男性與女性抗體暘性率[95.1％(135/142)比71.2％(99/139)]比較差異有統計學意義(x2=8.22,P＜0.01).結論 早期進行EV71-IgM和CA16-IgM抗體聯閤檢測,對臨床診斷手足口病及鑑控治療具有重要意義.
목적 탐토장도병독71형(EV71)화가살기병독A16형(CA16)항체사사재수족구병중적응용급상관성.방법 채용매련면역흡부법대학진적281례수족구병환인진행혈청EV71-IgM항체화CA16-IgM항체검측.결과 EV71-IgM항체양성144례(51.2％,144/281),CA16-IgM항체양성90례(32.0％,90/281),EV71-IgM화CA16-IgM쌍양성17례(6.0％,17/281),즉항체양성학절례수위217례,항체양성솔위77.2％(217/281).EV71-IgM항체양성솔여CA16-IgM항체양성솔비교차이유통계학의의(x2=21.35,P＜0.01),총체남성여녀성항체양성솔[95.1％(135/142)비71.2％(99/139)]비교차이유통계학의의(x2=8.22,P＜0.01).결론 조기진행EV71-IgM화CA16-IgM항체연합검측,대림상진단수족구병급감공치료구유중요의의.
Objective To investigate the application and correlation of enterovirus 71(EV71)and Coxsackie virus A16(CA16)antibody screening in the hand,foot and mouth disease(HFMD).Methods The method of enzyme linked immunosorbent assay was used to test the serum antibody of EV71-IgM and CA16-IgM in 281 patients(142 male and 139 female)with HFMD.Results The positive rate of EV71-IgM antibody was 51.2％(144/281),the positive rate of CA16-IgM antibody was 32.0％(90/281).Seventeen patients(6.0％,17/281)had dual positive of EV71-IgM and CA 16-IgM antibody.The total detection rate was 77.2％(217/281).The positive rate of EV71-IgM and CA16-IgM antibody had significant difference(x2 =21.35,P ＜ 0.01).The positive rate of EV71-IgM and CA16-IgM antibody in male had significant difference compared with female[95.1％(135/142)vs.71.2％(99/139),P＜ 0.01].Conclusions At the beginning of the illness should use the joint detection of EV71-IgM and CA16-IgM antibody diagnose HFMD.It has significance in diagnosing and monitoring.
