CAJ | 학술논문

目的探讨复方丹参片联合福善美(阿仑磷酸钠)治疗妇女绝经后骨质疏松症,评价其疗效及安全性.方法将180例绝经后骨质疏松症患者随机分为福善美组、丹参组和复方丹参片联合福善美组(简称联合组).分别采用相应药物进行治疗,疗程6个月,比较2组碱性磷酸酶、骨钙素、尿钙、尿肌酐、尿羟脯氨酸含量及腰1～5骨密度值.结果联合组的碱性磷酸酶、骨钙素、尿钙、尿肌酐、尿羟脯氨酸、腰1～5骨密度值与其他2组比较差异显著.结论福善美联合复方丹参片治疗绝经后妇女骨质疏松症安全有效.
목적 탐토복방단삼편연합복선미(아륜린산납)치료부녀절경후골질소송증,평개기료효급안전성.방법 장180례절경후골질소송증환자수궤분위복선미조、단삼조화복방단삼편연합복선미조(간칭연합조).분별채용상응약물진행치료,료정6개월,비교2조감성린산매、골개소、뇨개、뇨기항、뇨간포안산함량급요1～5골밀도치.결과 연합조적감성린산매、골개소、뇨개、뇨기항、뇨간포안산、요1～5골밀도치여기타2조비교차이현저.결론 복선미연합복방단삼편치료절경후부녀골질소송증안전유효.
Objective To assess whether treatment with compound danshen tablets plus alendronate would be safe and effective in women with postmenopausal osteoporosis. Methods 180 women with postmenopausal osteoporosis were randomized to receive combination therapy and independent therapy with compound danshen tablets and alendronate for 6 months. Scores of VRS were assessed,mean serum alkaline phosphatase, serum osteocalcin, urinary creatinine, urinary hydroxyproline, urinary calcium were detected. Bone mineral density of lumbar vertebra 1 ~5 was determined by dual X - ray absorptiometry. Results Mean serum alkaline phosphatase, serum osteocalcin, and urinary creatinine, urinary hydroxyproline, urinary calcium were statistically different between the combination therapy group and the independent therapy group, and bone mineral densities increased in all therapy groups while there was higher elevated level in the combination therapy group. Conclusions The combination therapy of compound danshen tablets with alendronate has a favorable influence on women with postmenopausal osteoporosis.