CAJ | 학술논문

目的了解我国Liddle综合征的临床特点及探讨其早期诊断,提高临床认识水平.方法回顾性分析本院1例Liddle综合征及国内杂志发表文献共23篇,总共58例的临床资料.结果男37例,女21例,比例为1.8:1,年龄14～71岁,平均(31.4±15.2)岁,首发症状,高血压39.7％ (23/58),乏力、低钾临床表现8.6％(5/58),同时出现高血压、低血钾12.1％ (7/58),无症状体检发现39.7％ (23/58)；发病年龄10～59岁,平均(22.3±10.4)岁,发病到确诊时间0～30年,平均(8.2±9.6)年；血压130～290/70～240mmHg,平均(收缩压195.96 ±39.66,舒张压123.67±29.1 mmHg)；合并脑卒中20.7％ (12/58)；10.3％ (6/58)仅低钠饮食或补钾即维持正常血压和血钾,55.2％( 32/58)低钠饮食、氨苯蝶啶及补钾后可控制血压和血钾,13.8％ (8/58)通过低钠饮食、阿米洛利及补钾治疗,15.5％(9/58)患者需要加用其他降压药方能控制血压.结论 Liddle综合征是一种可以得到很好治疗和控制的疾病,早发现、早诊断、早治疗可避免严重并发症的发生.
목적 료해아국Liddle종합정적림상특점급탐토기조기진단,제고림상인식수평.방법 회고성분석본원1례Liddle종합정급국내잡지발표문헌공23편,총공58례적림상자료.결과 남37례,녀21례,비례위1.8:1,년령14～71세,평균(31.4±15.2)세,수발증상,고혈압39.7％ (23/58),핍력、저갑림상표현8.6％(5/58),동시출현고혈압、저혈갑12.1％ (7/58),무증상체검발현39.7％ (23/58)；발병년령10～59세,평균(22.3±10.4)세,발병도학진시간0～30년,평균(8.2±9.6)년；혈압130～290/70～240mmHg,평균(수축압195.96 ±39.66,서장압123.67±29.1 mmHg)；합병뇌졸중20.7％ (12/58)；10.3％ (6/58)부저납음식혹보갑즉유지정상혈압화혈갑,55.2％( 32/58)저납음식、안분접정급보갑후가공제혈압화혈갑,13.8％ (8/58)통과저납음식、아미락리급보갑치료,15.5％(9/58)환자수요가용기타강압약방능공제혈압.결론 Liddle종합정시일충가이득도흔호치료화공제적질병,조발현、조진단、조치료가피면엄중병발증적발생.
Objectives To analysis the features and the early diagnostic signs of Liddle syndrome in China.Methods We retrospectively analyzed the clinical date of 58 Liddle syndrome patients including 1 case in our hospital and other cases reported by 23 literatures in China.Results There were 37 males and 21 femals with the ratio of 1.8:1.The age was from 14 ～ 71 years old averaged( 31.4 ± 15.2) years.The rates for the initial symptoms of Liddle syndrome:hypertension were 39.7％ ( 23/58 ),fatigue and hypokalemia were 8.6％ ( 5/58 ),hypertension and Hypokalemia were 12.1％ (7/58),asymptomatic cases were 39.7％ (23/58).Onset ages were from 10 to 59 years old averaged (22.3 ± 10.4 ) years.The time from onset to diagnosis were from 0 to 30 years averaged ( 8.2 ± 9.6) years.Mean blood pressure of these patients was 130 ～290/70 ～ 240 mmHg,averaged (systolic pressure 195.96 ±39.66,diastolic pressure 123.67 ± 29.1 mmHg).The rates for Liddle syndrome complicated by stroke were 20.7％ (12/58).10.3％ (6/58)patients can maintain normal blood pressure and normokalemia only by given a low - sodium diet or supplying potassium treatment.55.2％ ( 32/58 ) patients need a low - sodium diet 、triamterene and supplying potassium treatment.13.8％ (8/58)patients were given a low -sodium diet、amiloride and supplying potassium treatment.and 15.5％ (9/58)patients should be given other antihypertensive agens to maintain normal blood pressure.Conclusions Liddle syndrome is a disease that can be well treated.So early detection、early diagnosis and treatment can prevent serious complications.