CAJ | 학술논문

核转录因子-κB(nuclear factor-kappaB,NF-κB)是一种重要的转录因子,近年来研究表明其不仅在免疫反应、炎症及细胞凋亡中起着重要作用.在病理性疼痛的发生发展过程中亦至关重要.现就NF-κB在病理性疼痛发生发展中作用的研究进展,对其详细的作用机制可能为疼痛性疾病的治疗提供一个良好的前景作一综述.
핵전록인자-κB(nuclear factor-kappaB,NF-κB)시일충중요적전록인자,근년래연구표명기불부재면역반응、염증급세포조망중기착중요작용.재병이성동통적발생발전과정중역지관중요.현취NF-κB재병이성동통발생발전중작용적연구진전,대기상세적작용궤제가능위동통성질병적치료제공일개량호적전경작일종술.
Nuclear factor-kappa B (NF-κB) is a major transcription factor. Recent studies have shown that NF-κB plays a crucial rule not only in immune response, inflammation and apoptosis, but also in the development and processing of pathological pain. This article reviews the research advance on roles of NF-κB in the development and processing of pathological pain. The further insights into its detailed mechanisms may provide a nice prospect for the therapy of painful diseases.