中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2012年
2期
93-96
,共4页
魏宏强%曹雍华%葛旭峰%康瑞
魏宏彊%曹雍華%葛旭峰%康瑞
위굉강%조옹화%갈욱봉%강서
舍曲林%抑郁障碍%米氮平%空腹血糖
捨麯林%抑鬱障礙%米氮平%空腹血糖
사곡림%억욱장애%미담평%공복혈당
Sertraline%Depressive disorder%Mirtazapine%Fasting blood glucose
目的 探讨米氮平对抑郁障碍患者空腹血糖(FBG)的影响.方法 将93例抑郁障碍患者采用随机数字表法随机分为米氮平组、米氮平联合舍曲林组(以下简称联合用药组)、舍曲林组,每组31例；治疗观察期均为12周；3组患者于治疗前及治疗后第4、8、12周末测定FBG进行比较.结果 米氮平组与联合用药组间FBG的差异无统计学意义(P＞0.05),而此上述2组FBG均高于舍曲林组,差异有统计学意义(P均＜0.05)；米氮平组和联合用药组基线与第4周末FBG比较,差异无统计学意义(P均＞0.05),而基线与第8周末或第12周末比较,差异有统计学意义(P均＜0.05)；舍曲林组基线与第4、8、12周末FBG比较,差异无统计学意义(P均＞0.05)；3组间在第4周末或第8周末出现空腹血糖过高(IFG)频率的差异无统计学意义(P均＞0.05),而在第12周末,米氮平组或联合用药组与舍曲林组间出现IFG频率的差异有统计学意义(P均＜0.05).结论 米氮平单一或联合舍曲林治疗既往无糖代谢异常的抑郁障碍患者可出现有临床意义的IFG,且IFG出现的频率可能有随时间延长而增加的趋势.
目的 探討米氮平對抑鬱障礙患者空腹血糖(FBG)的影響.方法 將93例抑鬱障礙患者採用隨機數字錶法隨機分為米氮平組、米氮平聯閤捨麯林組(以下簡稱聯閤用藥組)、捨麯林組,每組31例；治療觀察期均為12週；3組患者于治療前及治療後第4、8、12週末測定FBG進行比較.結果 米氮平組與聯閤用藥組間FBG的差異無統計學意義(P＞0.05),而此上述2組FBG均高于捨麯林組,差異有統計學意義(P均＜0.05)；米氮平組和聯閤用藥組基線與第4週末FBG比較,差異無統計學意義(P均＞0.05),而基線與第8週末或第12週末比較,差異有統計學意義(P均＜0.05)；捨麯林組基線與第4、8、12週末FBG比較,差異無統計學意義(P均＞0.05)；3組間在第4週末或第8週末齣現空腹血糖過高(IFG)頻率的差異無統計學意義(P均＞0.05),而在第12週末,米氮平組或聯閤用藥組與捨麯林組間齣現IFG頻率的差異有統計學意義(P均＜0.05).結論 米氮平單一或聯閤捨麯林治療既往無糖代謝異常的抑鬱障礙患者可齣現有臨床意義的IFG,且IFG齣現的頻率可能有隨時間延長而增加的趨勢.
목적 탐토미담평대억욱장애환자공복혈당(FBG)적영향.방법 장93례억욱장애환자채용수궤수자표법수궤분위미담평조、미담평연합사곡림조(이하간칭연합용약조)、사곡림조,매조31례；치료관찰기균위12주；3조환자우치료전급치료후제4、8、12주말측정FBG진행비교.결과 미담평조여연합용약조간FBG적차이무통계학의의(P＞0.05),이차상술2조FBG균고우사곡림조,차이유통계학의의(P균＜0.05)；미담평조화연합용약조기선여제4주말FBG비교,차이무통계학의의(P균＞0.05),이기선여제8주말혹제12주말비교,차이유통계학의의(P균＜0.05)；사곡림조기선여제4、8、12주말FBG비교,차이무통계학의의(P균＞0.05)；3조간재제4주말혹제8주말출현공복혈당과고(IFG)빈솔적차이무통계학의의(P균＞0.05),이재제12주말,미담평조혹연합용약조여사곡림조간출현IFG빈솔적차이유통계학의의(P균＜0.05).결론 미담평단일혹연합사곡림치료기왕무당대사이상적억욱장애환자가출현유림상의의적IFG,차IFG출현적빈솔가능유수시간연장이증가적추세.
Objective To explore the effects of mirtazapine on fasting blood glucose (FBG) in depressive patients.Methods Ninety-three patients were randomly divided into three groups with 31 in each,who were treated with mirtazapine,mirtazapine plus sertraline( combined),or sertraline for 12 weeks.The FBG were measured at baseline and at weeks 4,8 and 12.Results The mean FBG was not significantly different between the mirtazapine group and the combined group ( P ＞ 0.05 ),which were higher than the sertraline group( P ＜0.05).The mean FBG of the mirtazapine or the combined group was not significantly different at baseline and at weeks 4 ( P ＞ 0.05 ),but differences between baseline and at wccks 8 or 12 ( P ＜ 0.05 ) were significant.The mean FBG of the sertraline group was not statistically different between baseline and at weeks 4 or 8 or 12 (P ＞ 0.05).The rates of impaired fasting glucose (IFG) among three groups were not statistically different at weeks 4 or 8 ( P ＞ 0.05 ),but was significantly different between the mirtazapine or the combined group and the sertraline group at weeks 12 ( P ＜ 0.05 ).Conclusions The results indicate the treatment of mirtazapine could have influence on glucose metabolism.
