CAJ | 학술논문

目的探讨卵巢早衰患者血清抗苗勒管激素(AMH)水平的变化及其临床意义.方法卵巢早衰患者25例,酶联免疫吸附试验(ELISA)检测其血清AMH水平.20例健康妇女做为正常对照.结果卵巢早衰患者血清AMH水平明显低于正常对照组(P<0.01),其中有20例患者血清AMH水平为0 pmol/L.对另5例血清中测得AMH的卵巢早衰患者做人工周期,再hMG/hCG促排卵,其中2例有卵泡发育,1例妊娠.结论卵巢早衰患者血清AMH水平明显下降或测不到,测定患者血清AMH水平对诊断卵巢早衰及指导治疗具有一定意义.
목적 탐토란소조쇠환자혈청항묘륵관격소(AMH)수평적변화급기림상의의.방법 란소조쇠환자25례,매련면역흡부시험(ELISA)검측기혈청AMH수평.20례건강부녀주위정상대조.결과 란소조쇠환자혈청AMH수평명현저우정상대조조(P<0.01),기중유20례환자혈청AMH수평위0 pmol/L.대령5례혈청중측득AMH적란소조쇠환자주인공주기,재hMG/hCG촉배란,기중2례유란포발육,1례임신.결론 란소조쇠환자혈청AMH수평명현하강혹측불도,측정환자혈청AMH수평대진단란소조쇠급지도치료구유일정의의.
Objective To observe the changes of serum anti-mttllerian hormone (AMH) level in women with premature ovarian fail-ure (POF) and its clinical significance. Methods Fasting serum levels of AMH in 25 POF patients were measured with enzyme-linked im-mtmosorbent assay (ELISA). Twenty healthy women matched for age and body mass index (BMI) were chosen as controls. Results The serum AMH level in POF group was (1.1±0.1) pmol/L, which was significantly lower than that of control group(P < 0.01). The serum AMH levels in 20 patients of POF group were undetectable. The other 5 patients were treated with artificial cycle at first, and then ovulated with hMG/HCG.2 patients had ovulation and 1 patient was pregnant. Conclusion The serum AMH level in POF patients was significantly decreased, and the measure for serum AMH had some significance for POF diagnosis and treatment.