CAJ | 학술논문

目的探讨新生儿肺炎克雷伯菌败血症的临床特点及药敏特点,为早期诊治提供依据.方法对本院新生儿科30例确诊为肺炎克雷伯菌败血症的新生儿进行临床资料及药敏结果的回顾性分析.结果肺炎克雷伯菌败血症常可引起多脏器功能受损.30株肺炎克雷伯菌中检出产ESBLs菌株8株(占26.7%),非产ESBLs菌株22株(占73.3%).肺炎克雷伯菌对亚胺培南、阿米卡星敏感率达100%,对环丙沙星和庆大霉素的敏感率分别为90%及70%.肺炎克雷伯菌对大多数青霉素类及头孢菌素类药物不敏感.结论肺炎克雷伯菌败血症发病有增多趋势,且多为医院内感染,有部分为产超广谱β-内酰胺酶菌株,耐药性强,对常用的抗生素不敏感,应根据药敏试验结果应用抗生素,以提高临床治愈率.
목적 탐토신생인폐염극뢰백균패혈증적림상특점급약민특점,위조기진치제공의거.방법 대본원신생인과30례학진위폐염극뢰백균패혈증적신생인진행림상자료급약민결과적회고성분석.결과 폐염극뢰백균패혈증상가인기다장기공능수손.30주폐염극뢰백균중검출산ESBLs균주8주(점26.7%),비산ESBLs균주22주(점73.3%).폐염극뢰백균대아알배남、아미잡성민감솔체100%,대배병사성화경대매소적민감솔분별위90%급70%.폐염극뢰백균대대다수청매소류급두포균소류약물불민감.결론 폐염극뢰백균패혈증발병유증다추세,차다위의원내감염,유부분위산초엄보β-내선알매균주,내약성강,대상용적항생소불민감,응근거약민시험결과응용항생소,이제고림상치유솔.
Objective To study the clinical characteristics and the drug sensitivity of neonatalsepticemia caused by Klebsiella pneumoniae in order to provide the evidences for the diagnosis and treatment. Methods A retrospective analysis including clinical data and drug sensitivity results was made in 30 neonates with septicemia caused by Klebsiella pneumoniae. Results Neonatal septicemia caused by Klebsiella pneumoniae could be damaging to many organs. There were 8 ESBLs strains in 30 Klebsiella pneumoniae strains( was 26.7% ) ,and22 are negative ESBLs starins( was 73.3% ). It was 100% of the Klebsiella pneumoniae strains were sensitive to carbapenems such as inipenem and panipenem, but there were 90% and 70% to each gentamicin and ciprofloxacin. Klebsiella pneumoniae were not sensitve to much of penicillin and cephalosporin. Conclusion The incidence of neonatal septicemia caused by Klebsiella pneumoniae wes higher than ever, and many of them were infected in hospital. Part of them were extended ESBLs and insensitive to the commonly used antibiotices. It is suggested the antibiotics should be used according to drug senitivity.