CAJ | 학술논문

穿透素3(pentraxin 3,PTX-3)是新发现的由感染和炎症部位组织细胞分泌的一种急性期蛋白,也是一种炎症标记物.PTX-3作为一个多功能的可溶性模式识别受体,在先天性免疫和炎症反应,肺部防御某些病原体感染中发挥着重要作用.在某些情况下,PTX-3的表达水平与肺组织的损伤程度高度相关.尽管目前对PTX-3在肺部表达的调节机制及其确切的生物学效能尚不十分清楚,但对其进一步研究为阐明炎症和急性肺损伤的发病机制及治疗提供了新的思路.
천투소3(pentraxin 3,PTX-3)시신발현적유감염화염증부위조직세포분비적일충급성기단백,야시일충염증표기물.PTX-3작위일개다공능적가용성모식식별수체,재선천성면역화염증반응,폐부방어모사병원체감염중발휘착중요작용.재모사정황하,PTX-3적표체수평여폐조직적손상정도고도상관.진관목전대PTX-3재폐부표체적조절궤제급기학절적생물학효능상불십분청초,단대기진일보연구위천명염증화급성폐손상적발병궤제급치료제공료신적사로.
Long pentraxin PTX -3 is a newly discovered acute phase protein and a marker of inflammation produced at the sites of infection and inflammation. In the process of preventing certain infection in the lung, PTX -3 acts as a muhifunctional soluble pattern recognition receptor connecting the innate immunity and inflammation. Under certain experimental conditions , such as high volume mechanical ventilation or severe bacterial infection, increased expression of PTX -3 in the lung is associated with more severe lung injury. Therefore, it is necessary to further explore the regulatory mechanisms of this over - expression. It is also essential to further determine the biological activities of PTX - 3. These studies will provide insight into the pathological processes of inflammation and acute lung injury, and provide potential novel therapeutic strategies to control pulmonary inflammation without severe lung injury.