激光杂志
激光雜誌
격광잡지
LASER JOURNAL
2011年
4期
58-60
,共3页
吴晓健%罗放%王济明%涂经楷
吳曉健%囉放%王濟明%塗經楷
오효건%라방%왕제명%도경해
肝细胞性肝癌%术后%复发
肝細胞性肝癌%術後%複髮
간세포성간암%술후%복발
hepatocellular carcinoma%post-operative%recurrence
目的：从临床角度发现影响肝癌术后复发的原因,预防性TACE在延缓肝癌手术后复发中的作用。方法：从1999年2月到2006年2月,连续性收治326例肝癌患者,所有患者均接受了肝癌切除术。将可能影响原发性肝癌术后复发的观察指标包括性别、年龄、术前AFP、有无癌栓、手术切缘、手术前肿瘤是否破裂、肿瘤大小、肿瘤有无子灶、肿瘤包膜情况、手术后有无行预防性TACE等,用Cox模型分析各因素与复发时间之间的关系。结果：年龄小、有癌栓、手术前肿瘤有破裂、肿瘤体积大和肿瘤周围有子灶等因素使肝癌手术后复发时间提前,保证较大手术切缘距离和手术后行预防性TACE可延缓肝癌手术后复发。结论：对于存在术后复发高危倾向的患者,在术前、术中及术后采取相应措施,可有效提高术后无瘤生存率、延长生存时间。术后施行TACE,可能对具有早期复发倾向的肝癌患者具有作用。
目的：從臨床角度髮現影響肝癌術後複髮的原因,預防性TACE在延緩肝癌手術後複髮中的作用。方法：從1999年2月到2006年2月,連續性收治326例肝癌患者,所有患者均接受瞭肝癌切除術。將可能影響原髮性肝癌術後複髮的觀察指標包括性彆、年齡、術前AFP、有無癌栓、手術切緣、手術前腫瘤是否破裂、腫瘤大小、腫瘤有無子竈、腫瘤包膜情況、手術後有無行預防性TACE等,用Cox模型分析各因素與複髮時間之間的關繫。結果：年齡小、有癌栓、手術前腫瘤有破裂、腫瘤體積大和腫瘤週圍有子竈等因素使肝癌手術後複髮時間提前,保證較大手術切緣距離和手術後行預防性TACE可延緩肝癌手術後複髮。結論：對于存在術後複髮高危傾嚮的患者,在術前、術中及術後採取相應措施,可有效提高術後無瘤生存率、延長生存時間。術後施行TACE,可能對具有早期複髮傾嚮的肝癌患者具有作用。
목적：종림상각도발현영향간암술후복발적원인,예방성TACE재연완간암수술후복발중적작용。방법：종1999년2월도2006년2월,련속성수치326례간암환자,소유환자균접수료간암절제술。장가능영향원발성간암술후복발적관찰지표포괄성별、년령、술전AFP、유무암전、수술절연、수술전종류시부파렬、종류대소、종류유무자조、종류포막정황、수술후유무행예방성TACE등,용Cox모형분석각인소여복발시간지간적관계。결과：년령소、유암전、수술전종류유파렬、종류체적대화종류주위유자조등인소사간암수술후복발시간제전,보증교대수술절연거리화수술후행예방성TACE가연완간암수술후복발。결론：대우존재술후복발고위경향적환자,재술전、술중급술후채취상응조시,가유효제고술후무류생존솔、연장생존시간。술후시행TACE,가능대구유조기복발경향적간암환자구유작용。
Objective：To evaluate prognostic factors that could affect disease-free survival and recurrence and evaluate effect of post-operative TACE in inhibiting recurrence for patients after liver resection for hepatocellular carcinoma（HCC）.Methods：A total of consecutive 326 patients with hepatocellular carcinoma from Feb.1999 to Feb.2006 were included in this study.All patients underwent hepatic resection.Variables might related with recurrence including sex,age,preoperative AFP level,vascular invasion,resection margin,tumor rapture,tumor size,number of nodule,tumor capsule and post-operative TACE were used in the multivariate analysis using the Cox proportional hazard model to analyze factors affecting intrahepatic recurrence.Results：On multivariate analysis by Cox proportional hazard model,younger HCC patients,presence of vascular invasion,presence of tumor rupture,larger in tumor diameter,presence of multiple nodules were significantly related to a higher incidence of tumor recurrence.Wider clearance resection margin and post-operative TACE were signiticantlv related to a lower incidence of tumor recurrence.Conclusion：Appropriate measures adopted pre-,during and post-operative may improve disease-free survival and survival time especially in patients who possess high risk factors for recurrence.Post-operative TACE might be effective for the patients who had HCC expressing early recurrence characteristic.
