中国中西医结合杂志
中國中西醫結閤雜誌
중국중서의결합잡지
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2009年
10期
869-871
,共3页
妊娠期肝内胆汁淤积症%复方丹参注射液%熊去氧胆酸%新生儿预后
妊娠期肝內膽汁淤積癥%複方丹參註射液%熊去氧膽痠%新生兒預後
임신기간내담즙어적증%복방단삼주사액%웅거양담산%신생인예후
intra-hepatic cholestasis in pregnant stage%compound salvia injection%ursodeoxycholic acid%predication on perinatal newborn
目的 评估复方丹参注射液联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症的临床疗效及对新生儿预后的影响.方法 选择妊娠期肝内胆汁淤积症患者128例,分成两组.治疗组72例采用复方丹参注射液(20 mL加入10%葡萄糖注射液500 mL静脉滴注,每天1次)和熊去氧胆酸[15 mg/(kg·d),分3次口服]联合治疗;对照组56例采用熊去氧胆酸治疗;均以14天为1个疗程.观察两组治疗前后瘙痒评分、血清生化指标[甘胆酸(CG)、总胆红素(TBiL)、谷丙转氨酶(ALT)及谷草转氨酶(AST)]变化及分娩后比较两组围生儿情况.结果 两组治疗后瘙痒评分均明显降低,治疗组由3.6分降至1..4分,对照组由3.4分降至1.6分,两组评分比较差异无统计学意义(P>0.05),但起效时间治疗组(4～6天)较对照组(8～10天)更快;两组血清CG、TBiL、ALT及AST均较治疗前下降(P<0.01),治疗组较对照组下降更明显,差异有统计学意义(P<0.05).治疗后两组间胎儿窘迫、羊水粪染和新生儿窒息发生率比较,差异均无统计学意义(P>0.05);但新生儿体重治疗组[(3 108±236)g]大于对照组[(2 681±269)g],差异有统计学意义(P<0.05).结论 复方丹参注射液联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症,疗效优于单用熊去氧胆酸治疗者.
目的 評估複方丹參註射液聯閤熊去氧膽痠治療妊娠期肝內膽汁淤積癥的臨床療效及對新生兒預後的影響.方法 選擇妊娠期肝內膽汁淤積癥患者128例,分成兩組.治療組72例採用複方丹參註射液(20 mL加入10%葡萄糖註射液500 mL靜脈滴註,每天1次)和熊去氧膽痠[15 mg/(kg·d),分3次口服]聯閤治療;對照組56例採用熊去氧膽痠治療;均以14天為1箇療程.觀察兩組治療前後瘙癢評分、血清生化指標[甘膽痠(CG)、總膽紅素(TBiL)、穀丙轉氨酶(ALT)及穀草轉氨酶(AST)]變化及分娩後比較兩組圍生兒情況.結果 兩組治療後瘙癢評分均明顯降低,治療組由3.6分降至1..4分,對照組由3.4分降至1.6分,兩組評分比較差異無統計學意義(P>0.05),但起效時間治療組(4～6天)較對照組(8～10天)更快;兩組血清CG、TBiL、ALT及AST均較治療前下降(P<0.01),治療組較對照組下降更明顯,差異有統計學意義(P<0.05).治療後兩組間胎兒窘迫、羊水糞染和新生兒窒息髮生率比較,差異均無統計學意義(P>0.05);但新生兒體重治療組[(3 108±236)g]大于對照組[(2 681±269)g],差異有統計學意義(P<0.05).結論 複方丹參註射液聯閤熊去氧膽痠治療妊娠期肝內膽汁淤積癥,療效優于單用熊去氧膽痠治療者.
목적 평고복방단삼주사액연합웅거양담산치료임신기간내담즙어적증적림상료효급대신생인예후적영향.방법 선택임신기간내담즙어적증환자128례,분성량조.치료조72례채용복방단삼주사액(20 mL가입10%포도당주사액500 mL정맥적주,매천1차)화웅거양담산[15 mg/(kg·d),분3차구복]연합치료;대조조56례채용웅거양담산치료;균이14천위1개료정.관찰량조치료전후소양평분、혈청생화지표[감담산(CG)、총담홍소(TBiL)、곡병전안매(ALT)급곡초전안매(AST)]변화급분면후비교량조위생인정황.결과 량조치료후소양평분균명현강저,치료조유3.6분강지1..4분,대조조유3.4분강지1.6분,량조평분비교차이무통계학의의(P>0.05),단기효시간치료조(4～6천)교대조조(8～10천)경쾌;량조혈청CG、TBiL、ALT급AST균교치료전하강(P<0.01),치료조교대조조하강경명현,차이유통계학의의(P<0.05).치료후량조간태인군박、양수분염화신생인질식발생솔비교,차이균무통계학의의(P>0.05);단신생인체중치료조[(3 108±236)g]대우대조조[(2 681±269)g],차이유통계학의의(P<0.05).결론 복방단삼주사액연합웅거양담산치료임신기간내담즙어적증,료효우우단용웅거양담산치료자.
Objective To evaluate the therapeutic effect of compound salvia injection combined with ursodeoxycholic acid(UDCA)in treating pregnant women with intrahepatic cholestasis(ICP)and its influence on perinatal babies.Methods One hundred and twenty-eight patients of ICP were assigned to two groups.The 72 patients in the treatment group were treated with salvia injection(20 mL in 10% glucose 500 mL for intravenous dripping once a day)and UDCA(15 mg,thrice daily by oral taken),and the 56 patients in the control group were treated with UDCA alone,all were treated for 14 days.Changes of itching symptom(estimated by scoring)and serum levels of biochemical indexes,including alanine aminotransferase(ALT),aspartate amonitransferase(AST),bilirubin(TBil)and glycocholic acid(GCA),were determined before and after treatment,and conditions of the newborns were compared after delivery.Results Compared with before treatment,scores of itching were lowered from 3.6 scores to 1.4 scores in the treatment group,and from 3.4 scores to 1.6 scores in the control group,showing no significant difference between groups(P>0.05),but the lowering was shown earlier in the former.Levels of biochemical indexes were improved significantly(P<0.01)in both groups,but the improvements were more significant in the treatment group,the difference between groups was significant(P<0.05).The difference between groups in the incidence of fetal distress,meconium-stained fluid and neonatal asphysia were insignificant(P>0.05).The birth weights of the newborns were higher in the treatment group than in the control group(3 108±236 g vs 2 681±269 g,P<0.05).Conclusion The combined therapy of compound salvia injection and UDCA shows better effect in treating ICP than that of UDCA alone.
