临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
JOURNAL OF CLINICAL PSYCHOSOMATIC DISEASES
2009年
4期
320-321
,共2页
情感障碍%躁狂发作%碳酸锂%丙戊酸镁%Beek-Rafaelsen躁狂量表%副反应量表
情感障礙%躁狂髮作%碳痠鋰%丙戊痠鎂%Beek-Rafaelsen躁狂量錶%副反應量錶
정감장애%조광발작%탄산리%병무산미%Beek-Rafaelsen조광량표%부반응량표
Affective disorder%manic episode%lithium carbonade%magnesium valproate%BRMS%TESS
目的 探讨碳酸锂联合丙戊酸镁治疗躁狂发作的临床疗效与安全性. 方法 将80例躁狂发作患者随机分成两组各40例,两组均口服碳酸锂治疗,研究组联合丙戊酸镁治疗,观察6 w.于治疗前及治疗第1 w、2 w、4 w、6 w末采用Beek-Rafaelsen躁狂量表及副反应量表评定临床疗效及不良反应. 结果 治疗6 w末,研究组显效率显著高于对照组(P＜0.05),总有效率无显著性差异(P＞0.05);两组治疗后Beek-Rafaelsen躁狂量表评分均较治疗前有显著下降(P均＜0.01),研究组治疗1 w、4 w、6 w末均较对照组下降显著(P＜0.05或0.01);两组不良反应发生率及副反应量表总分均无显著性差异(P＞0.05),血锂浓度均维持在0.8 mmol～1.1 mmol·L-1. 结论 碳酸锂联合丙戊酸镁治疗躁狂发作疗效优于单用碳酸锂,且起效快,血锂浓度均维持在安全治疗窗范围内,不增加药物不良反应,是治疗躁狂发作的有效方案.
目的 探討碳痠鋰聯閤丙戊痠鎂治療躁狂髮作的臨床療效與安全性. 方法 將80例躁狂髮作患者隨機分成兩組各40例,兩組均口服碳痠鋰治療,研究組聯閤丙戊痠鎂治療,觀察6 w.于治療前及治療第1 w、2 w、4 w、6 w末採用Beek-Rafaelsen躁狂量錶及副反應量錶評定臨床療效及不良反應. 結果 治療6 w末,研究組顯效率顯著高于對照組(P＜0.05),總有效率無顯著性差異(P＞0.05);兩組治療後Beek-Rafaelsen躁狂量錶評分均較治療前有顯著下降(P均＜0.01),研究組治療1 w、4 w、6 w末均較對照組下降顯著(P＜0.05或0.01);兩組不良反應髮生率及副反應量錶總分均無顯著性差異(P＞0.05),血鋰濃度均維持在0.8 mmol～1.1 mmol·L-1. 結論 碳痠鋰聯閤丙戊痠鎂治療躁狂髮作療效優于單用碳痠鋰,且起效快,血鋰濃度均維持在安全治療窗範圍內,不增加藥物不良反應,是治療躁狂髮作的有效方案.
목적 탐토탄산리연합병무산미치료조광발작적림상료효여안전성. 방법 장80례조광발작환자수궤분성량조각40례,량조균구복탄산리치료,연구조연합병무산미치료,관찰6 w.우치료전급치료제1 w、2 w、4 w、6 w말채용Beek-Rafaelsen조광량표급부반응량표평정림상료효급불량반응. 결과 치료6 w말,연구조현효솔현저고우대조조(P＜0.05),총유효솔무현저성차이(P＞0.05);량조치료후Beek-Rafaelsen조광량표평분균교치료전유현저하강(P균＜0.01),연구조치료1 w、4 w、6 w말균교대조조하강현저(P＜0.05혹0.01);량조불량반응발생솔급부반응량표총분균무현저성차이(P＞0.05),혈리농도균유지재0.8 mmol～1.1 mmol·L-1. 결론 탄산리연합병무산미치료조광발작료효우우단용탄산리,차기효쾌,혈리농도균유지재안전치료창범위내,불증가약물불량반응,시치료조광발작적유효방안.
Objeceive To explore the efficacy and safety of lithium carbonate plus magnesium valproate in the treatment of manic episode.Methods 80 patients with manic episode were randomly divided into two troups of 40 ones each, both groups took orally lithium carbonate,and research group was added magnesium ralproate to for 6 weeks. Efficacies were assessed with the Bech-Rafaelsen Mania Rating Scale (BRMS) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) before treatment and at the end of the 1st,2nd,4th and 6th week. Results At the end of the 6th week,obvious effective rate was significantly higher in the research than in the control group(P<0.05),there was no significant difference in total effective rate(P>0.05);after treatment, BRMS scores of both groups lowered more significantly compared with pretreatment(both P<0.01),so did in the research than in the control group at the end of the 1st,4th and 6th week(P<0.05 or 0.01);there were no significant differences in incidences of adverse reactions and total scores of the TESS(P>0.05),blood lithium concentrations maintained 0.8 mmol～1.1 mmol/L. Conclusion Lithium carbonaste combined with magnesium valproate has an advantage over single lithium carbonade,takes effect quickly, blood lithium concentrations maintained within safe therapeutic window limit,doesn't increase drug adverse reactions and is an effective schedule treating manic episode.
