CAJ | 학술논문

目的验证曲唑酮对抑郁症伴失眠患者的安眠作用。方法35例单相抑郁发作或双相情感障碍抑郁发作伴有明显失眠者，汉密尔顿抑郁量表(HAMD)得分≥24分完成4周治疗。结果治疗前后两组病人总睡眠时间、早醒延迟时间、夜间觉醒次数与治疗前相比有明显改善(P＜0.05)。HAMD睡眠因子分两组治疗前后明显改善(P＜0.05或P＜0.01)。曲唑酮能显著改善深度睡眠。除口干、便秘发生频率较高外(P＜0.05)，曲唑酮其它副作用发生频率不高于舒乐安定。结论曲唑酮的安眠作用值得推荐应用。
목적험증곡서동대억욱증반실면환자적안면작용。방법35례단상억욱발작혹쌍상정감장애억욱발작반유명현실면자，한밀이돈억욱량표(HAMD)득분≥24분완성4주치료。결과치료전후량조병인총수면시간、조성연지시간、야간각성차수여치료전상비유명현개선(P＜0.05)。HAMD수면인자분량조치료전후명현개선(P＜0.05혹P＜0.01)。곡서동능현저개선심도수면。제구간、편비발생빈솔교고외(P＜0.05)，곡서동기타부작용발생빈솔불고우서악안정。결론곡서동적안면작용치득추천응용。
Objective To investigate the hypnotic effect of trazodone on depression patients with insomnia. Method 35 cases with single episode of depression or depressive phase of bipolar affective disorder accompanied by apparent insomnia and Hamilton depression scale (HAMD) score ≥ 24 accepted four - week treatment with trazodone. Result At the end of trial, total sleeping time, postponement of earlyawakening and frequencies of waking up in sleeping time had significantly improved than those of before the treatment( P ＜ 0.05) in bothgroups. Sleeping factors of HAMD were markedly improved, too( P ＜ 0. 05 or P ＜ 0. 01 ) . The other benefit of trazodone focused on im-proving the deep sleeping. The side effects of trazodone developed no more frequenly than those of surazepam except for dry mouth and constipation( P ＜ 0. 05). Conclusion It was worth applying the hypnotic effect of trazodone for the improvement of depression patients withinsomnia.