CAJ | 학술논문

目的：探讨nm23基因蛋白二磷酸核苷激酶（NDPK）在卵巢上皮癌中的表达及其临床意义。方法：应用免疫组化S-P法，检测nm23基因蛋白在45例卵巢上皮癌，12例卵巢交界性瘤及10例良性卵巢上皮性肿瘤组织中的表达。结果：卵巢上皮癌nm23基因蛋白表达阳性率为73.3%，明显高于卵巢良性上皮肿瘤（30.0%）和卵巢交界性上皮肿瘤（41.7%）差异显著（P<0.05）。nm23基因蛋白表达强度与卵巢上皮癌的组织学类型，癌组织的分化程度无明显关系，而与卵巢上皮癌的临床分期有关（P<0.05）。卵巢上皮癌nm23基因蛋白阳性患者术后生存期明显高于nm23基因蛋白阴性患者（P<0.05）。结论：nm23基因蛋白的表达可以作为判断卵巢癌患者预后的一个有价值的指标。
목적：탐토nm23기인단백이린산핵감격매（NDPK）재란소상피암중적표체급기림상의의。방법：응용면역조화S-P법，검측nm23기인단백재45례란소상피암，12례란소교계성류급10례량성란소상피성종류조직중적표체。결과：란소상피암nm23기인단백표체양성솔위73.3%，명현고우란소량성상피종류（30.0%）화란소교계성상피종류（41.7%）차이현저（P<0.05）。nm23기인단백표체강도여란소상피암적조직학류형，암조직적분화정도무명현관계，이여란소상피암적림상분기유관（P<0.05）。란소상피암nm23기인단백양성환자술후생존기명현고우nm23기인단백음성환자（P<0.05）。결론：nm23기인단백적표체가이작위판단란소암환자예후적일개유개치적지표。
Objective: Our purpose was to study the expression of protein of nm23 gene in patients with epithelial ovarian carcinoma.Methods:Protein of nm23 gene was detected by immunohistochemical technique in 45 patients with epithelial ovarian cancer, 12 with borderline, and 10 with benign ovarian tumor.Results:The positive expression rate in ovarian cancer (73.3%) was significantly higher than that of the benign and borderline tumors. There was no significant correlation between the expression of nm23 gene and the histological type, grade, the existence of ascites or the size of residul after operation. However, the expression of nm23 gene protein was negatively related with the FIGO stage. The overall survival rate of the patients with positive expression of nm23 gene was much higher than that of the patients with negative expression. Conclusion:The findings suggest that nm23 gene protein might serve as a valuable and independent marker for the prognosis of ovarian cancer.