CAJ | 학술논문

本文用细胞内微注射法对不同强度的脉冲磁场对细胞缝隙连接通讯(GJIC)功能的效应进行了研究，并与正弦磁场的作用以及脉冲磁场所感生的不同电场的作用进行了比较和探索。研究发现0.41mT以上强度的脉冲磁场具有抑制GJIC的作用，这种作用与磁场强度有关。其抑制GJIC的效应比正弦磁场为强。经相同磁场不同强度感应电场作用的比较，得出，GJIC的抑制主要由磁场引起，而与感应电场关系不大。本文首次从研究对GJIC的作用提供了脉冲磁场治疗创伤愈合等有关理论依据。
본문용세포내미주사법대불동강도적맥충자장대세포봉극련접통신(GJIC)공능적효응진행료연구，병여정현자장적작용이급맥충자장소감생적불동전장적작용진행료비교화탐색。연구발현0.41mT이상강도적맥충자장구유억제GJIC적작용，저충작용여자장강도유관。기억제GJIC적효응비정현자장위강。경상동자장불동강도감응전장작용적비교，득출，GJIC적억제주요유자장인기，이여감응전장관계불대。본문수차종연구대GJIC적작용제공료맥충자장치료창상유합등유관이론의거。
Effects of 50Hz pulsing magnetic fields (PMFs) on gap junctional intercellular communication (GJIC) were studied by using microinjection, and compared with the effects of 50Hz sinusoidal magnetic fields (SMFs). The effects caused by different intensities of induced electric fields (EFs) at the same intensity of PMFs and the same exposure duration were also examined. The results showed that PMFs more than 0.4 mT could inhibit GJIC, which was more significant than that induced by SMFs, and no "amplitude window" effect was found, but there was an intensity-effect relationship. In addition, it showed that the suppression to GJIC was mainly caused by direct action of PMFs rather than induced EFs by way of the comparative study of effects induced by different intensities of EFs with the same magnetic flux density. We first reported the results of our study on the effects of PMFs on GJIC and provided related theoretical basis for healing of fracture and other wound with PMFs.