CAJ | 학술논문

目的：探讨先天性心脏病(简称先心病)重度肺动脉高压的手术治疗效果和转化生长因子β1(TGF-β1)表达的关系以及后者对手术时机选择的指导意义。　方法：对29例先心病重度肺动脉高压患者行终止分流手术的随访资料进行分析，用免疫组化染色观察肺活检组织TGF-β1的表达。　结果：TGF-β1在血管壁内皮细胞的阳性表达率为89.65%，在基质的阳性表达率为55.17%，且在病理分级Ⅰ～Ⅱ与Ⅲ级以上的基质中阳性表达率差异显著(P<0.05)。　结论：TGF-β1在先心病肺动脉高压的形成过程中起重要作用，且其表达对指导临床患者选择手术时机有一定的参考价值。
목적：탐토선천성심장병(간칭선심병)중도폐동맥고압적수술치료효과화전화생장인자β1(TGF-β1)표체적관계이급후자대수술시궤선택적지도의의。　방법：대29례선심병중도폐동맥고압환자행종지분류수술적수방자료진행분석，용면역조화염색관찰폐활검조직TGF-β1적표체。　결과：TGF-β1재혈관벽내피세포적양성표체솔위89.65%，재기질적양성표체솔위55.17%，차재병리분급Ⅰ～Ⅱ여Ⅲ급이상적기질중양성표체솔차이현저(P<0.05)。　결론：TGF-β1재선심병폐동맥고압적형성과정중기중요작용，차기표체대지도림상환자선택수술시궤유일정적삼고개치。
Objectives:To study the pathological behavior and the value of transforming growth factor β1(TGF-β1) in predicting prognosis in pulmonary hypertension associated with congenital heart disease.　Methods:Lung tissues from 29 patients with congenital heart diseases associated with pulmonary hypertension were examined by surgical biopsy of the lung. All samples were examined for the expression and localization of TGF-β1 by immunohistochemical technique with anti-TGF-β1 antibody.　Results:Twenty-six out of 29 showed positive staining of intracellular endotheliocyte TGF-β1(89.65%),16 samples showed extracellular matrix TGF-β1 staining(55.17%).Statistically, there was significant difference between Ⅰ～Ⅱ and Ⅲ～Ⅵ pathological degrees in extracellular matrix(P<0.05).　Conclusions: TGF-β1 plays an important biological role in the formation of pulmonary hypertension after congenital heart disease. It is conductive in predicting prognosis.