CAJ | 학술논문

为探讨在高温环境下纳络酮能否预防小鼠中暑的发生，在42 ℃人工气温室，给小鼠腹腔注射不同剂量的纳络酮，分别观察不同剂量组小鼠受热180，240，330 min的生存率及平均生存时间。结果：(1)不同时间内各剂量组小鼠存活率均较对照组降低；(2)在240 min受热时间内，随剂量的增加存活率有增高的趋势，超过240 min后，这一趋势消失；(3)低、中、高剂量组平均生存时间分别为(239.35±83.99)，(275.00±71.40)，(299.65±46.46)min，均比对照组(317.90±45.51)min降低。结果提示纳络酮在预防小鼠42 ℃高温中暑及提高生存率方面无明显作用。
위탐토재고온배경하납락동능부예방소서중서적발생，재42 ℃인공기온실，급소서복강주사불동제량적납락동，분별관찰불동제량조소서수열180，240，330 min적생존솔급평균생존시간。결과：(1)불동시간내각제량조소서존활솔균교대조조강저；(2)재240 min수열시간내，수제량적증가존활솔유증고적추세，초과240 min후，저일추세소실；(3)저、중、고제량조평균생존시간분별위(239.35±83.99)，(275.00±71.40)，(299.65±46.46)min，균비대조조(317.90±45.51)min강저。결과제시납락동재예방소서42 ℃고온중서급제고생존솔방면무명현작용。
In order to know whether Naloxone can prevent mice from heat stroke,the survival rate and ave\|rage survival time of mice administrated with different doses of Naloxone at 180,240 and 330 min after exposed to 42 ℃in an environment cabinet were observed.The results were as follows:(1)Survival rates of all dosage group at all different exposure periods were lower than those of the control.(2)Accompanied with the increase of injec\|ted dosage of Naloxone,the survival rate increased within 240 min,whereas beyond 240 min this trend diminished.(3)The average survival times of low,medium and high dose groups were 239.35±83.99，275.00±71.40 and 299.65±46.46 min respectively.They all were lower than that of the control(317.90±45.51 min).These results suggest that no significance of Naloxone was found in prevention of heat stroke in mice and in increase of survival rate when exposed to 42℃.Q