中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2001年
1期
14-17
,共4页
过氧化氢%离子通道%Ca2+稳态
過氧化氫%離子通道%Ca2+穩態
과양화경%리자통도%Ca2+은태
H2O2对细胞膜上不同的离子通道有广泛的作用, 而且同一种通道在不同的组织类型中对H2O2的反应性亦不同。在培养的lymnaea（椎螺）神经元中，H2O2可诱导剂量依赖性的内向Ca2+电流的降低，L-型Ca2+电流的降低,导致通道失活。在绵羊心肌细胞的内质网H2O2可直接调节Ca2+释放通道，使其开放概率（P0）增加，但它不影响电导。H2O2对K＋通道的作用表明，H2O2介导的KCa通道活性改变因组织类别的不同而亦有差异。H2O2可诱导豚鼠心肌细胞ATP-敏感K＋通道的活动增加。H2O2对全细胞Na+通道的影响及对单通道Na+电流的影响目前报道极少。
H2O2對細胞膜上不同的離子通道有廣汎的作用, 而且同一種通道在不同的組織類型中對H2O2的反應性亦不同。在培養的lymnaea（椎螺）神經元中，H2O2可誘導劑量依賴性的內嚮Ca2+電流的降低，L-型Ca2+電流的降低,導緻通道失活。在綿羊心肌細胞的內質網H2O2可直接調節Ca2+釋放通道，使其開放概率（P0）增加，但它不影響電導。H2O2對K＋通道的作用錶明，H2O2介導的KCa通道活性改變因組織類彆的不同而亦有差異。H2O2可誘導豚鼠心肌細胞ATP-敏感K＋通道的活動增加。H2O2對全細胞Na+通道的影響及對單通道Na+電流的影響目前報道極少。
H2O2대세포막상불동적리자통도유엄범적작용, 이차동일충통도재불동적조직류형중대H2O2적반응성역불동。재배양적lymnaea（추라）신경원중，H2O2가유도제량의뢰성적내향Ca2+전류적강저，L-형Ca2+전류적강저,도치통도실활。재면양심기세포적내질망H2O2가직접조절Ca2+석방통도，사기개방개솔（P0）증가，단타불영향전도。H2O2대K＋통도적작용표명，H2O2개도적KCa통도활성개변인조직유별적불동이역유차이。H2O2가유도돈서심기세포ATP-민감K＋통도적활동증가。H2O2대전세포Na+통도적영향급대단통도Na+전류적영향목전보도겁소。
The H2O2 has been shown to have comprahensive actions on various ion channels of cell membrane. But it has different effects on different tissues. H2O2-induced a dose dependent decreasing L- type Ca2+ current on cultrued Lymnaea neurons. In sheep cardiac SR, H2O2 plays an important role in regulating directly on RyR Ca2+-release channel that caused an increasing of P0, but it was no effects on conductance. It indicated that H2O2-induced different activities on KCa channel with different tissues. In guinea pig ventricular myocytes, H2O2-induced increase in KATP channels. There are few data on the effects of H2O2 on whole cell Na+ currents and single Na+ channels.
