CAJ | 학술논문

目的探讨进驻高海拔地区血小板活化程度及血栓素A2(TXA2 )与前列环素(PGI2)的代谢产物血栓素B2(TXB2)和6-酮-前列腺素F1α( 6-Keto-PGF1α)的变化。方法对从平原进驻海拔5380 m高原第7天及半年的20名青年进行血浆α-颗粒膜蛋白(GMP-140)、TXB2、Keto-PGF1α、血管性假血友病因子 (vWF)及纤维蛋白原 (Fg)检测，并与20名平原健康青年作对照。结果进驻海拔5380 m高原第7天及半年较平原GMP-140、TXB2 、TXB2/6-Keto-PGF1α(T/K)、vWF、Fg均显著增高，6-Keto-PGF1α显著降低(P<0.05或P<0.01)。进驻5380 m第7天较半年GMP-140、TX B2、T/K、vWF及Fg显著增高(P<0.01)，6-Keto-PGF1α显著降低(P<0.05)。结论高原低氧促使血小板活化，TXA2合成增加和(或 )PGI2生成减少导致TXA2/PGI2平衡失调，参与了低氧性肺动脉高压的形成。
목적 탐토진주고해발지구혈소판활화정도급혈전소A2(TXA2 )여전렬배소(PGI2)적대사산물혈전소B2(TXB2)화6-동-전렬선소F1α( 6-Keto-PGF1α)적변화。 방법 대종평원진주해발5380 m고원제7천 급반년적20명청년진행혈장α-과립막단백(GMP-140)、TXB2、Keto-PGF1α、혈 관성가혈우병인자 (vWF)급섬유단백원 (Fg)검측，병여20명평원건강청 년작대조。 결과 진주해발5380 m고원제7천급반년교평원GMP-140、TXB2 、TXB2/6-Keto-PGF1α(T/K)、vWF、Fg균현저증고，6-Keto-PGF1α현저 강저(P<0.05혹P<0.01)。진주5380 m제7천교반년GMP-140、TX B2、T/K、vWF급Fg현저증고(P<0.01)，6-Keto-PGF1α현저강저(P<0.05)。 결론 고원저양촉사혈소판활화，TXA2합성증가화(혹 )PGI2생성감 소도치TXA2/PGI2평형실조，삼여료저양성폐동맥고압적형성。
Objective To explore the platelet activation level and the cha nges of thromboxane B2(TXB2) and 6-Keto-Prostaglandin F1α(6-Keto- PGF1α)which are metabolites of thromboxane A2 (TXA2) and prostacyclin (PGI2)u nder altitude condition. Method Levels of GMP-140，TXB2，6-Keto-PGF1 α，TXB2/6-Keto-PGF1α(T/K)，vWF and Fg in serum were examined in 20 healthy young adults on the 7th day a fter ascending to an altitude of 5380 m from sea level and after stayed there for 6 months.The data were compared with those at sea level. Result The levels of GMP-140，TXB2，T/K，vWF and Fg were remarkably higher at 5380 m altitude on the 7th day and after stayed fo r 6 months than at sea level.While the level of 6-Keto-PGF1αwere decreased signif icantly (P<0.05 or P<0.01). Conclusion High altitude hypoxia,platelet activation, overproduction of TXA2,and decrease of PGI2 lead to imbalance of TXA 2/PGI2 and appeared to be associated with the development of hypoxic pulmonary hypertensi on.