CAJ | 학술논문

目的：观察人胎盘提取液对高脂鼠脂蛋白-胆固醇代谢及血小板聚集功能的影响。方法：Wistar大鼠定量给予高脂饲料建立高脂模型，用胎盘提取液4ml/(kg.d)连续灌胃12d，测定血脂，脂蛋白；血浆中前列环素(PGI2)，血栓素A2(TxA2)含量及血小板最大聚集率(MA)。结果：胎盘提取液可使高脂鼠血清中高密度脂蛋白明显升高，甘油三酯、胆固醇、低密度脂蛋白含量明显降低(P＜0.01)；使血浆中前列环素含量明显升高(P＜0.01)，TxA2含量无明显变化，并明显降低MA(P＜0.01)。结论：胎盘提取液通过改善脂蛋白-胆固醇代谢及抑制血小板聚集的综合效应拮抗动脉粥样硬化的发生和发展。
목적：관찰인태반제취액대고지서지단백-담고순대사급혈소판취집공능적영향。방법：Wistar대서정량급여고지사료건립고지모형，용태반제취액4ml/(kg.d)련속관위12d，측정혈지，지단백；혈장중전렬배소(PGI2)，혈전소A2(TxA2)함량급혈소판최대취집솔(MA)。결과：태반제취액가사고지서혈청중고밀도지단백명현승고，감유삼지、담고순、저밀도지단백함량명현강저(P＜0.01)；사혈장중전렬배소함량명현승고(P＜0.01)，TxA2함량무명현변화，병명현강저MA(P＜0.01)。결론：태반제취액통과개선지단백-담고순대사급억제혈소판취집적종합효응길항동맥죽양경화적발생화발전。
Objective:To study the effect of human placental extract (HPE) onlipoprotein-cholesterol metabolism and platelet aggregation function in hyperlipemia rats.Method:Wistar mouse hyperlipemia model was established by given HPE 4 ml/(kg.d) through stomach for 12 days.Then the contents of their serum triglyceride (TG),cholesterol (CHO),low density lipoprotein (LDL-C),high density lipoprotein (HDL-C),and its subcomponent HDL2-C;PGI2,TxA2 in plasma and maximum platelet aggregation rate(MA) were tested.Result:HPE increased the contents of HDL-C,HDL2-C PGI2 (P＜0.01) and decreased the contents of TG,TC,LDL-C (P＜0.01) in hyperlipemia rats.In addition,the PGI2 level was increased (P＜0.01)and MA was decreased (P＜0.01) in plasma.There was no changes about the contents of plasma TxA2.Conclusion:HPE may ameliorate lipoprotein cholesterol metabolic disorder of hyperlipemia rats and inhibit platelet aggregation which may be beneficial to resist the occurrence and development of atherosclerosis.