CAJ | 학술논문

目的研究生物活性玻璃陶瓷（BGC）人工骨植入下颌骨缺损远期的组织学及超微结构变化。方法对2例因肿瘤行部分下颌骨切除生物活性玻璃陶瓷植入术后8～10年的BGC标本用电子显微镜进行超微结构观察，部分样本脱钙后行HE染色组织学观察，并与植入前的BGC作对照。结果材料与其外侧的板状骨结合紧密，多数板状骨以钉突形式长入材料中，晶体孔隙间充满了骨样组织；脱钙后组织学观察见大量纤维结缔组织长入材料中，材料中心亦有管状骨长入。结论 BGC复合自体骨植入有良好的骨替代效果，克服其脆性后有较大的临床应用前景。
목적 연구생물활성파리도자（BGC）인공골식입하합골결손원기적조직학급초미결구변화。방법 대2례인종류행부분하합골절제생물활성파리도자식입술후8～10년적BGC표본용전자현미경진행초미결구관찰，부분양본탈개후행HE염색조직학관찰，병여식입전적BGC작대조。결과 재료여기외측적판상골결합긴밀，다수판상골이정돌형식장입재료중，정체공극간충만료골양조직；탈개후조직학관찰견대량섬유결체조직장입재료중，재료중심역유관상골장입。결론 BGC복합자체골식입유량호적골체대효과，극복기취성후유교대적림상응용전경。
Objective To study the histological changes and ultramicroscopicstructure differences between primary bioactive glass ceramics(BGC) and that implanted in mandible as bone substitute for 8～10 years. Methods Specimens retreved from two patients were obtained and electric scanning microscope and HE staining were employed. Results The new bone fixed tightly with less than 10 μm space at the interface between new bone and BGC,bone tissue extends into the material via pin-like structure or even to the center of the BGC block.Fibrous tissue could penetrate the whole thickness of the BGC(10mm),the space of BGC crystalline fulfilled with bone-like materials. Conclusion BGC and host bone complex implantation result in satisfactory functional and esthetics outcomes,to overcome its fatigue could result in prosperous future.