CAJ | 학술논문

Objective: To observe the therapeutic effect of electroacupuncture (EA) of "Zusanli"(ST 36) and"Weishu"(BL 21 )on the experimental gastric ulcer in Xu-period of a day for analyzing the best opportunity of acupunc-with 7 rats in each group. Rat gastric ulcer model was established using intra-gastric administration of glacial aceticacid. Gastric mucosal thickness, mucosal muscular defect width, superficial mucosal mucus index (MI), intramucosal MI, Total MI, plasma 6-keto-PGF1α, serum NO and gastric tissue CGRP concentrations were used as the indexes. The EAtreatment was conducted once daily at Xu-period (7-9 o'clock in the evening), Chen-period (8- 10 o'clock in themorning) and irregular time (IT) with 6 days being a therapeutic course, two courses altogether. Results: After EAand BL-21-Xu group, were all apparently higher than that of control group (P＜ 0.05-0.01 ), while the mucosal mus-cle layer defect width values of different EA groups, particularly ST-36-Xu group and BL-21-Xu group, were strikinglythe 6 EA groups, particularly those of ST-36-Xu and BL-21-Xu groups, were all significantly higher than that of controlof ST-36-Xu and BL-21-Xu groups and CGRP concentration of ST-36-Chen group, were all significantly higher thanNO level (r ＝ 0. 858, 0. 987, P ＜ 0.05, and 0.01 ), and between the superficial mucus index and CGRP concentration(r ＝ 0. 905 1, t ＝ 4.68, P ＜ 0.01 ), suggesting that the increase of the secretion function of the regenerated mucosalmucus is related to acupuncture induced increase of release of both NO and CGRP. Conclusion:The therapeutic effect ofEA of ST-36 and BL-21 in Xu-period is better in the treatment of gastric ulcer,and that of EA of ST-36 is the best.