合成化学
閤成化學
합성화학
CHINESE JOURNAL OF SYNTHETIC CHEMISTRY
2002年
2期
170-171
,共2页
氨基腈基吡唑%丙二腈%原甲酸三乙酯%水合肼%佐匹隆%合成
氨基腈基吡唑%丙二腈%原甲痠三乙酯%水閤肼%佐匹隆%閤成
안기정기필서%병이정%원갑산삼을지%수합정%좌필륭%합성
aminocyanopyrazole%zaleplon%malononitrile%orthoformate%hydrazine hydrate%synthesis
经两步反应合成了3-氨基-4-腈基吡唑:丙二腈与原甲酸三乙酯反应得到乙氧亚甲基丙二腈;其产物再与水合肼反应得到3-氨基-4-腈基吡唑,总收率为68.3%.
經兩步反應閤成瞭3-氨基-4-腈基吡唑:丙二腈與原甲痠三乙酯反應得到乙氧亞甲基丙二腈;其產物再與水閤肼反應得到3-氨基-4-腈基吡唑,總收率為68.3%.
경량보반응합성료3-안기-4-정기필서:병이정여원갑산삼을지반응득도을양아갑기병이정;기산물재여수합정반응득도3-안기-4-정기필서,총수솔위68.3%.
3-Amino-4-cyanopyrazole has been synthesized by a convenient two-step process. First malononitrile reacted with ethyl orthoformate to give ethoxymethylenemalononitrile, then 3-amino-4-cyanopyrazole was obtained through the reaction of ethoxymethylenemalononitrile with hydrazine hydrate. The overall yield was 68.3%.
