CAJ | 학술논문

为探讨高胆红素血症新生儿的脑功能状态，早期评估其预后，对80例新生儿黄疸行血清胆红素测定，并进行脑干听觉诱发电位（ABR）检查。结果显示，血清胆红素137～171μmol／L36例（Ⅰ组），其中20例ABR异常，异常率55.6％；～205μmol／L30例（Ⅱ组），其中28例ABR异常，异常率93.3％；～257μmol／L14例（Ⅲ组），其ABR全部异常。Ⅰ组与Ⅱ组比较，ABR异常率差异有高度显著性（P＜0．01），Ⅱ组与Ⅲ组比较，差异无显著性（P＞0．05）。胆红素浓度恢复正常后3个月复查，恢复率为Ⅰ组100％，Ⅱ组42.9％，Ⅲ组均未恢复，组间比较差异有高度显著性（P＜0．01）。认为ABR与新生儿血清胆红素浓度呈相关性，当血清胆红素浓度达到171μmol／L时，应予以高度重视，以免导致永久性中枢神经损伤。
위탐토고담홍소혈증신생인적뇌공능상태，조기평고기예후，대80례신생인황달행혈청담홍소측정，병진행뇌간은각유발전위（ABR）검사。결과현시，혈청담홍소137～171μmol／L36례（Ⅰ조），기중20례ABR이상，이상솔55.6％；～205μmol／L30례（Ⅱ조），기중28례ABR이상，이상솔93.3％；～257μmol／L14례（Ⅲ조），기ABR전부이상。Ⅰ조여Ⅱ조비교，ABR이상솔차이유고도현저성（P＜0．01），Ⅱ조여Ⅲ조비교，차이무현저성（P＞0．05）。담홍소농도회복정상후3개월복사，회복솔위Ⅰ조100％，Ⅱ조42.9％，Ⅲ조균미회복，조간비교차이유고도현저성（P＜0．01）。인위ABR여신생인혈청담홍소농도정상관성，당혈청담홍소농도체도171μmol／L시，응여이고도중시，이면도치영구성중추신경손상。
To evaluate the prognosis of newborns with hyperbilirubinemia as early as possible by study the brain function of those newborns，serum bilirubin concentration（SBC）and auditory brainstem responese （ABR）were detected in 80 newborns with hyperbilirubinemia．Results showed that among the 36 cases with the SBC in the range of 137 to 171 μmol／L（the first group），there were 20 cases with abnormal ABR，the rate of abnormal incidence was 55．6％ Among the 30 cases with the SBC in the range of 171 to 205 μmol／L（the second group），there were 28 cases with abnormal ABR，the rate of abnormal incidence was 93．3％．There were 14 cases with the SBC in the range of 205 to 257 μmol／L（the third group）whose ABRwere all abnormal．The difference was highly significant between the first and the second group（P＜0．01），it was no significant between the second and the third group（P＞0．05）．After three months，the cases with abnormal ABR were detected again．The results showed that the rate of resumption of the first group was 100％，the rate of resumption of the second group was 42．9％，but the ABR of the third group were still all abormal．The differences were highly significant（P＜0．01）．It suggests that ABR are associated with the neonatal SBC，it should be highly watched out when SBC rise to 171 μmol／L，or which woud result in perpetual damage on the centrical nervous svstem in newborns．