CAJ | 학술논문

高迁移率族蛋白A2(high mobility group A2, HMGA2)是一种非组蛋白染色体蛋白,本身无转录活性,但是可以通过改变染色质结构来调节其他基因的转录.HMGA2在正常组织中低表达或不表达,而在胚胎期以及恶性肿瘤组织中的表达明显上调.在一些恶性肿瘤中,HMGA2可以作为诊断分子标志物或判断预后的独立因子.此外,HMGA2能够促进上皮-间质转化以及维持干细胞的分化潜能和自我更新能力,在肿瘤的发生、生长和转移等方面可能发挥着重要作用.
고천이솔족단백A2(high mobility group A2, HMGA2)시일충비조단백염색체단백,본신무전록활성,단시가이통과개변염색질결구래조절기타기인적전록.HMGA2재정상조직중저표체혹불표체,이재배태기이급악성종류조직중적표체명현상조.재일사악성종류중,HMGA2가이작위진단분자표지물혹판단예후적독립인자.차외,HMGA2능구촉진상피-간질전화이급유지간세포적분화잠능화자아경신능력,재종류적발생、생장화전이등방면가능발휘착중요작용.
The high mobility group A2 (HMGA2) is a non-histone chromatin protein. It has no transcriptional activity of itself but could alter chromatin structure to regulate the transcription of other genes. HMGA2 gene is weakly expressed or does not express in normal tissues. The expression of HMGA2 is up-regulated during embryogenesis and malignant neoplasias. In several malignant tumors, HMGA2 is used as a diagnostic molecular marker or an independent prognostic indicator. Furthermore, HMGA2 not only elicits epithelial-mesenchymal transition but also maintains the differentiation potential and self-regeneration capability of stem cells. It plays an important role in initiation, proliferation, and metastasis of malignant neoplasias.