CAJ | 학술논문

间充质干细胞(MSC)已成功从动物体尤其骨髓中分离获得.干细胞,具有向多种组织和细胞如骨、脂肪、成软骨细胞等分化的潜能,这种潜能越来越引起人们关注,它可向受损的组织定向迁移以修复受损组织.体外资料研究表明,不管协同刺激信号存在与否,都具有低免疫原性.在体外MSC还具有免疫抑制活性,可抑制同种异体抗原或丝裂霉素刺激的T细胞扩增,阻止细胞毒性T细胞增殖,同时还具有调节炎性细胞的免疫活性使其向抗炎细胞分化的作用.因此,系统了解.MSC的生物学、免疫学特性将为人们深入阐明其免疫调节机制,并将其用于治疗自身免疫性病、组织修复及移植提供依据.
간충질간세포(MSC)이성공종동물체우기골수중분리획득.간세포,구유향다충조직화세포여골、지방、성연골세포등분화적잠능,저충잠능월래월인기인문관주,타가향수손적조직정향천이이수복수손조직.체외자료연구표명,불관협동자격신호존재여부,도구유저면역원성.재체외MSC환구유면역억제활성,가억제동충이체항원혹사렬매소자격적T세포확증,조지세포독성T세포증식,동시환구유조절염성세포적면역활성사기향항염세포분화적작용.인차,계통료해.MSC적생물학、면역학특성장위인문심입천명기면역조절궤제,병장기용우치료자신면역성병、조직수복급이식제공의거.
Mesenchymal stem cell(MSC)have been identified in animals.As stem cells.thev have the a-bility to differentiate into multiple cell types,such as bone,fat and cartilage cells.This potentiaJ might pro-vide exciting therapeutic possibilities. MSC prerentially home to damaged tissue and may have therapeutic potential.In vitro data suggested that MSC had low inherent immunogenicity as they induce little,if any,proliferation of allogeneic lymphocytes.Instead,MSC appear to be immunosuppressive in vitro.They can in-hibit T-cell proliferation stimulated with alloantigens or mitogens,and prevent the development of cytotoxic T-cell,as well as possess the possible immunoregulation to different inflammatory cells.A better understanding of the MSC immunoregulation mechanism will provide possible clinical applications ining autojmmune disor-ders,tissue repair,therapy-resistant sever acute graft-versus-host disease and in the treatment of organ al-lografts rejection.