中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
5期
535-536
,共2页
夏经钢%尹春琳%曲杨%郝恒剑%徐东
夏經鋼%尹春琳%麯楊%郝恆劍%徐東
하경강%윤춘림%곡양%학항검%서동
高血压%非心脏手术%氨氯地平/阿托伐他汀%保护作用
高血壓%非心髒手術%氨氯地平/阿託伐他汀%保護作用
고혈압%비심장수술%안록지평/아탁벌타정%보호작용
Hypertension%Non-cardiac surgery%Amlodipine/atorvastatin%Protection
目的 探讨氨氯地平阿托伐他汀在行非心脏手术的高血压病患者围术期的降压疗效及对心脑血管的保护作用.方法 选2011年5-7月在骨外科、普通外科和泌尿科拟行外科手术的高血压病患者80例,年龄40～75岁,同质配对分为治疗组(口服苯磺酸氨氯地平阿托伐他汀钙)和对照组(口服硝苯地平缓释片),各40例.术前根据血压情况服药3～5d,控制血压低于140/90 mm Hg(1 mm Hg =0.133 kPa),观察并比较2组患者手术当日清晨、围术期平均血压,记录急性心肌梗死、急性左心衰竭、脑梗死和脑出血等心脑血管不良事件发生率.结果 治疗组手术当日清晨和围术期平均血压明显低于对照组,组间比较差异均有统计学意义[手术当日清晨平均血压:(137±7)/(76±5)mm Hg比(142 ±9)/(92±4)mm Hg,围术期血压:(133±8)/(75±5)mm Hg比(139±9)/(84±5)mm Hg,P＜0.01)；治疗组心脑血管不良事件发生率为5.0％ (2/40),低于对照组[10.0％(4/40)],组间比较差异有统计学意义(P＜0.05).结论 氨氯地平阿托伐他汀钙可平稳控制行非心脏手术高血压病患者围术期血压,有效降低晨峰高血压,同时对心脑血管具有保护作用.
目的 探討氨氯地平阿託伐他汀在行非心髒手術的高血壓病患者圍術期的降壓療效及對心腦血管的保護作用.方法 選2011年5-7月在骨外科、普通外科和泌尿科擬行外科手術的高血壓病患者80例,年齡40～75歲,同質配對分為治療組(口服苯磺痠氨氯地平阿託伐他汀鈣)和對照組(口服硝苯地平緩釋片),各40例.術前根據血壓情況服藥3～5d,控製血壓低于140/90 mm Hg(1 mm Hg =0.133 kPa),觀察併比較2組患者手術噹日清晨、圍術期平均血壓,記錄急性心肌梗死、急性左心衰竭、腦梗死和腦齣血等心腦血管不良事件髮生率.結果 治療組手術噹日清晨和圍術期平均血壓明顯低于對照組,組間比較差異均有統計學意義[手術噹日清晨平均血壓:(137±7)/(76±5)mm Hg比(142 ±9)/(92±4)mm Hg,圍術期血壓:(133±8)/(75±5)mm Hg比(139±9)/(84±5)mm Hg,P＜0.01)；治療組心腦血管不良事件髮生率為5.0％ (2/40),低于對照組[10.0％(4/40)],組間比較差異有統計學意義(P＜0.05).結論 氨氯地平阿託伐他汀鈣可平穩控製行非心髒手術高血壓病患者圍術期血壓,有效降低晨峰高血壓,同時對心腦血管具有保護作用.
목적 탐토안록지평아탁벌타정재행비심장수술적고혈압병환자위술기적강압료효급대심뇌혈관적보호작용.방법 선2011년5-7월재골외과、보통외과화비뇨과의행외과수술적고혈압병환자80례,년령40～75세,동질배대분위치료조(구복분광산안록지평아탁벌타정개)화대조조(구복초분지평완석편),각40례.술전근거혈압정황복약3～5d,공제혈압저우140/90 mm Hg(1 mm Hg =0.133 kPa),관찰병비교2조환자수술당일청신、위술기평균혈압,기록급성심기경사、급성좌심쇠갈、뇌경사화뇌출혈등심뇌혈관불량사건발생솔.결과 치료조수술당일청신화위술기평균혈압명현저우대조조,조간비교차이균유통계학의의[수술당일청신평균혈압:(137±7)/(76±5)mm Hg비(142 ±9)/(92±4)mm Hg,위술기혈압:(133±8)/(75±5)mm Hg비(139±9)/(84±5)mm Hg,P＜0.01)；치료조심뇌혈관불량사건발생솔위5.0％ (2/40),저우대조조[10.0％(4/40)],조간비교차이유통계학의의(P＜0.05).결론 안록지평아탁벌타정개가평은공제행비심장수술고혈압병환자위술기혈압,유효강저신봉고혈압,동시대심뇌혈관구유보호작용.
Objective To observe the effect of amlodipine/atorvastatin on perioperative blood pressure in hypertensive patients during non-cardiac surgery.Methods Totally 80 patients with hypertension were divided into two groups,a ged 40-75 years old,in May-July 2011 when they are in bone surgery,general surgery and urology surgery.There were 40 cases in the amlodipine/atorvastatin calcium treatment group and 40 cases in the nifedipine control group.Morning blood pressure in the day of surgery,averge blood pressure,angina pectoris,acute myocardial infarction,acute left heart failure,transient ischemic attack,cerebral infarction,cerebral hemorrhage and incidence of adverse events in the two groups were observed and compared.Results Morning blood pressure in the day of surgery and perioperative average blood pressure in the treatment group were significantly lower than those in the control group.There were one case of angina and one case of transient ischemic attack in treatment group; there were one case of angina,one case of left ventricular failure,one case of transient ischemic attack and one case of cerebral infarction in the control group.Cardiovascular and cerebrovascular adverse events in both groups were significantly different.Conclusion Amlodipine/atorvastatin in hypertensive patients with non-cardiac surgery can control perioperative blood pressure stably and safely.
