中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2009年
1期
30-33
,共4页
王坤%王瑞%刘正亮%门金龙%万恩广%孔令敏%王金鹏%沈超%李扬
王坤%王瑞%劉正亮%門金龍%萬恩廣%孔令敏%王金鵬%瀋超%李颺
왕곤%왕서%류정량%문금룡%만은엄%공령민%왕금붕%침초%리양
矽肺%一氧化氮%痰%硝酸盐类%酪氨酸
矽肺%一氧化氮%痰%硝痠鹽類%酪氨痠
석폐%일양화담%담%초산염류%락안산
Silicosis%Nitric oxide%Sputum%Nitrates%Tyrosine
目的 分析矽肺患者和接尘工人诱导痰中NO2-/NO3-硝化酪氨酸的含量变化,探讨一氧化氮代谢产物作为矽肺早期炎性标志物的可行性.方法 以80名矽尘接触工人为接尘组,84名矽肺患者为病例组,30名无矽尘接触史的后勤人员为对照组,测定诱导痰中一氧化氮代谢产物NO2-/NO3-硝化酪氨酸的含量,并进行NO2-/NO3-硝化酪氨酸水平与接尘工龄、肺功能各项指标的相关分析.结果 接尘组诱导痰中NO2-/NO3-水平[60.30(46.58)μmol/L]明显高于对照组[36.90(22.28)μmol/L],而病例组[79.65(89.10)μmol/L]明显高于接尘组和对照组,差异均有统计学意义(P<0.05);接尘组和病例组诱导痰中NO2-/NO3-水平与接尘工龄呈正相关(r值分别为0.3733和0.3830,P<0.05),与FVC%、FEVI10、PEF%、MEF25%、MEF50%均旱负相关(r值分别为0.1540、0.1723、0.1535、0.1485、0.1643,P<0.05).接尘组和病例组诱导痰中硝化酪氨酸水平分别为[3.51(0.46)nmol/L]和[3.48(0.49)nmo/L],明显高于对照组,差异有统计学意义(P<0.05);诱导痰硝化酪氨酸水平与接尘工龄和肺通气功能指标皆无相火性(P0.05).结论 诱导痰中NO2-/NO3-水平与接尘工龄呈正相关,NO2-/NO3-作为矽肺早期炎性标志物具有一定的可行性.
目的 分析矽肺患者和接塵工人誘導痰中NO2-/NO3-硝化酪氨痠的含量變化,探討一氧化氮代謝產物作為矽肺早期炎性標誌物的可行性.方法 以80名矽塵接觸工人為接塵組,84名矽肺患者為病例組,30名無矽塵接觸史的後勤人員為對照組,測定誘導痰中一氧化氮代謝產物NO2-/NO3-硝化酪氨痠的含量,併進行NO2-/NO3-硝化酪氨痠水平與接塵工齡、肺功能各項指標的相關分析.結果 接塵組誘導痰中NO2-/NO3-水平[60.30(46.58)μmol/L]明顯高于對照組[36.90(22.28)μmol/L],而病例組[79.65(89.10)μmol/L]明顯高于接塵組和對照組,差異均有統計學意義(P<0.05);接塵組和病例組誘導痰中NO2-/NO3-水平與接塵工齡呈正相關(r值分彆為0.3733和0.3830,P<0.05),與FVC%、FEVI10、PEF%、MEF25%、MEF50%均旱負相關(r值分彆為0.1540、0.1723、0.1535、0.1485、0.1643,P<0.05).接塵組和病例組誘導痰中硝化酪氨痠水平分彆為[3.51(0.46)nmol/L]和[3.48(0.49)nmo/L],明顯高于對照組,差異有統計學意義(P<0.05);誘導痰硝化酪氨痠水平與接塵工齡和肺通氣功能指標皆無相火性(P0.05).結論 誘導痰中NO2-/NO3-水平與接塵工齡呈正相關,NO2-/NO3-作為矽肺早期炎性標誌物具有一定的可行性.
목적 분석석폐환자화접진공인유도담중NO2-/NO3-초화락안산적함량변화,탐토일양화담대사산물작위석폐조기염성표지물적가행성.방법 이80명석진접촉공인위접진조,84명석폐환자위병례조,30명무석진접촉사적후근인원위대조조,측정유도담중일양화담대사산물NO2-/NO3-초화락안산적함량,병진행NO2-/NO3-초화락안산수평여접진공령、폐공능각항지표적상관분석.결과 접진조유도담중NO2-/NO3-수평[60.30(46.58)μmol/L]명현고우대조조[36.90(22.28)μmol/L],이병례조[79.65(89.10)μmol/L]명현고우접진조화대조조,차이균유통계학의의(P<0.05);접진조화병례조유도담중NO2-/NO3-수평여접진공령정정상관(r치분별위0.3733화0.3830,P<0.05),여FVC%、FEVI10、PEF%、MEF25%、MEF50%균한부상관(r치분별위0.1540、0.1723、0.1535、0.1485、0.1643,P<0.05).접진조화병례조유도담중초화락안산수평분별위[3.51(0.46)nmol/L]화[3.48(0.49)nmo/L],명현고우대조조,차이유통계학의의(P<0.05);유도담초화락안산수평여접진공령화폐통기공능지표개무상화성(P0.05).결론 유도담중NO2-/NO3-수평여접진공령정정상관,NO2-/NO3-작위석폐조기염성표지물구유일정적가행성.
Objective To analyze the change in nitration tyrosine,NO2-/NO3- level in induced sputum of silicosis patients and dust exposure workers and to evaluate the approach and feasibility of nitric oxide(NO) metabolites as early detection indicators of silicosis.Methods Nitration tyrosine,NO2-/NO3- concentration in induced sputum of 80 dust exposure workers,84 silicosis patients,30 logistic personnel with no history of expo-sure to silica dust were determined and the relationship among Nitration tyrosine,NO2-/NO3- level and dust ex-posure years as well as pulmonary function tests were analyzed.Results μ NO2-/NO3- level among exposed group[60.30(46.58)μmol/l] was significantly higher than the control group[36.90( 22.28 )μmol/l],(P<0.05),and the level of NO2-/NO3- among the cases [79.65 (89.10)μmol/l] was significantly higher than exposed group as well as the control group(P<0.05 ).Compared with control,the level of nitration tyrosine in exposed group[3.51 (0.46) nmol/l] and the cases[3.48 (0.49)nmul/t] was significantly higher(P<0.05 ).NO2-/NO3- level and dust exposure,years were positively correlated ( r=0.3733 and 0.3830 respectirely P<0.05 ) ;NO2-/NO3- level and pul-monary function tests ( FVC%,FEV10%,PEF%,MEF25%,MEF50% ) were negatively correlated (r=0.1540,0.1723,0.1535,0.1485,0.1643 respectirely,P<0.05 ).There was no correlation between nitration tyrosinc and dust exposure years (P0.05),no correlation between nitration tyrosine and pulmonary function test (P0.05).Conclusion The level of NO2-/NO3- level in induced sputum has a positive correlation with exposure to dust,suggesting that there will be a certain feasibility of the NO2-/NO3- as indicators of early detection of silicosis.
