CAJ | 학술논문

目的:研究比较不同吸收促进剂对苦参碱体内外吸收作用的影响.方法:苦参碱于大鼠小肠的体外渗透速率由非翻转小肠囊法测定,其体内活性通过小鼠急性肝损伤模型评价.结果:在受试的吸收促进荆中,只有Tween 80和脱氧胆酸钠(SDC)能够增加苦参碱在大鼠小肠黏膜的渗透量.0.5%SDC的体外吸收促进作用最好,增渗比为1.6.其体内活性的评价显示,对于急性肝损伤模型小鼠,服用含0.5%SDC的苦参碱溶液较不合吸收促进荆的苦参碱溶液体内活性明显提高.结论:吸收促进剂能明显改善苦参碱的体内外吸收.
목적:연구비교불동흡수촉진제대고삼감체내외흡수작용적영향.방법:고삼감우대서소장적체외삼투속솔유비번전소장낭법측정,기체내활성통과소서급성간손상모형평개.결과:재수시적흡수촉진형중,지유Tween 80화탈양담산납(SDC)능구증가고삼감재대서소장점막적삼투량.0.5%SDC적체외흡수촉진작용최호,증삼비위1.6.기체내활성적평개현시,대우급성간손상모형소서,복용함0.5%SDC적고삼감용액교불합흡수촉진형적고삼감용액체내활성명현제고.결론:흡수촉진제능명현개선고삼감적체내외흡수.
Aim: To investigate the enhancement of enhancers on matrine in vitro and in vivo. Methods: The permeability of matrine across rat intestine was determined by non-everted intestinal sacs model in vitro, and the in vivo activity was assayed in a model of acute liver injury in mice. Sodium deoxycholate (SDC) was selected as the enhancer Candidate. Results: Among the tested absorption enhancers, only polysorbate 80 (Tween 80) and SDC showed to be capable of increasing the transport of matrine through small intestinal mucosa in rats.Enhancement ratios of 1.6 was observed for 0.5% SDC solutions with the best absorption enhancement for matrine in vitro, it was chosen to conduct hepatoprotective study in vivo. In mice with acute liver injury, combination of matrine with 0.5% SDC demonstrated considerably more activity than matrine along after oral administration. Conclusion: The results indicated that the absorption of matrine could be significantly improved by the absorption enhancer.