中华核医学杂志
中華覈醫學雜誌
중화핵의학잡지
CHINESE JOURNAL OF NUCLEAR MEDICINE
2008年
2期
121-123
,共3页
何薇%毛金磊%蒋茂松%陈绍亮
何薇%毛金磊%蔣茂鬆%陳紹亮
하미%모금뢰%장무송%진소량
炎症%放射性核素显像%环丙沙星%免疫球蛋白类%锝%兔
炎癥%放射性覈素顯像%環丙沙星%免疫毬蛋白類%锝%兔
염증%방사성핵소현상%배병사성%면역구단백류%득%토
Inflammation%Radionuclide imaging%Ciprofloxacin%Immunoglobulins%Technetium%Rabbits
目的 通过炎症兔模型99Tcm-环丙沙星与99Tcm-非特异性人多克隆免疫球蛋白(HIgG)显像的比较,评估99Tcm-环丙沙星的特异性.方法 建立4组兔模型.组1为无菌性炎症模型,组2为细菌性炎症模型,组3为右后肢无菌性炎症、左后肢细菌性炎症模型,组4为空白对照组.各组饲养7 d后行99Tcm-环丙沙星显像,2 d后再行99Tcm-HIgG显像,并比较2次显像结果.结果 静脉注射99Tcm-环丙沙星1 h炎症部位就显影,延迟至3～4 h,图像更清晰.组1无菌性炎症兔模型99Tcm-环丙沙星显像明性,99Tcm-HIgG阳性.组2细菌性炎症兔模型99Tcm-环丙沙星和99Tcm-HIgG显像均为阳性.组399Tcm-环丙沙星显像在左后肢细菌性炎症中有异常放射性分布,右后肢非细菌性炎症中未见明显显影;99Tcm-HIgG显像在左后肢细菌性炎症和右后肢非细菌性炎症中均有放射性浓聚.组4则2种显像均为阴性.结论 99Tcm-环丙沙星能特异定位细菌性炎症灶,在非细菌性炎症部位无浓聚.最佳显像时间为给药后3 h.
目的 通過炎癥兔模型99Tcm-環丙沙星與99Tcm-非特異性人多剋隆免疫毬蛋白(HIgG)顯像的比較,評估99Tcm-環丙沙星的特異性.方法 建立4組兔模型.組1為無菌性炎癥模型,組2為細菌性炎癥模型,組3為右後肢無菌性炎癥、左後肢細菌性炎癥模型,組4為空白對照組.各組飼養7 d後行99Tcm-環丙沙星顯像,2 d後再行99Tcm-HIgG顯像,併比較2次顯像結果.結果 靜脈註射99Tcm-環丙沙星1 h炎癥部位就顯影,延遲至3～4 h,圖像更清晰.組1無菌性炎癥兔模型99Tcm-環丙沙星顯像明性,99Tcm-HIgG暘性.組2細菌性炎癥兔模型99Tcm-環丙沙星和99Tcm-HIgG顯像均為暘性.組399Tcm-環丙沙星顯像在左後肢細菌性炎癥中有異常放射性分佈,右後肢非細菌性炎癥中未見明顯顯影;99Tcm-HIgG顯像在左後肢細菌性炎癥和右後肢非細菌性炎癥中均有放射性濃聚.組4則2種顯像均為陰性.結論 99Tcm-環丙沙星能特異定位細菌性炎癥竈,在非細菌性炎癥部位無濃聚.最佳顯像時間為給藥後3 h.
목적 통과염증토모형99Tcm-배병사성여99Tcm-비특이성인다극륭면역구단백(HIgG)현상적비교,평고99Tcm-배병사성적특이성.방법 건립4조토모형.조1위무균성염증모형,조2위세균성염증모형,조3위우후지무균성염증、좌후지세균성염증모형,조4위공백대조조.각조사양7 d후행99Tcm-배병사성현상,2 d후재행99Tcm-HIgG현상,병비교2차현상결과.결과 정맥주사99Tcm-배병사성1 h염증부위취현영,연지지3～4 h,도상경청석.조1무균성염증토모형99Tcm-배병사성현상명성,99Tcm-HIgG양성.조2세균성염증토모형99Tcm-배병사성화99Tcm-HIgG현상균위양성.조399Tcm-배병사성현상재좌후지세균성염증중유이상방사성분포,우후지비세균성염증중미견명현현영;99Tcm-HIgG현상재좌후지세균성염증화우후지비세균성염증중균유방사성농취.조4칙2충현상균위음성.결론 99Tcm-배병사성능특이정위세균성염증조,재비세균성염증부위무농취.최가현상시간위급약후3 h.
Objective 99Tcm-ciprofloxacin(Infecton)and 99Tcm-HIgG are both radiopharmaceuticals for inflammation and infectious disease imaging.It was reported that99Tcm-ciprofloxacin (Infecton)Was able to distinguish inflammation from infection.while 99Tcm-HIgG was a nonspecific agent.The study Was designed to compare the in vivo characteristics between 99Tcm-ciprofloxacin(Infecton)and 99Tcm-HIgG in rabbit model of inflammation.Methods Eight rabbits were grouped as inflammation model(the first group).infection model(the second group),concomitant inflammation and infection model(the third group),and control(the fourth group)groups.A total of 185 MBq(0.5 m1)99Tcm-ciprofloxacin(Infecton)Was administered intravenously to each rabbit.a serious dynamic images were acquired till 24 h post-injection.Repeated examination with99Tcm-HIgG was carried out 2 d later.Resuits 99Tcm-ciprofloxacin(Infecton)scan was negative in the inflammation models and controls.and was positive in the infection models.In the third group99Tcmciprofloxacin(Infecton)showed infection focus in the left thigh but negative uptake at inflammation focus in the right thigh.99Tcm-HIgG scan were positive in all models.The optimal image time for99Tcm-ciprofloxacin(Infecton)was 3 h after administration.but positive image could still be observed 24 h later.Conclusion 99Tcm-ciprofloxacin(Infecton)appears to specifically accumulate in the infective lesion.
