CAJ | 학술논문

采用NADPH二磷酸酶组织化学方法,研究先天性巨结肠症NANC抑制性神经系统.结果提示狭窄段肠管缺乏NOS阳性神经丛,肌层内有散在神经纤维,有时可见到粗纤维或小神经干;正常结肠和巨结肠正常段富含阳性神经节细胞和神经纤维.提示NO与先天性巨结肠发病机理有关.
채용NADPH이린산매조직화학방법,연구선천성거결장증NANC억제성신경계통.결과제시협착단장관결핍NOS양성신경총,기층내유산재신경섬유,유시가견도조섬유혹소신경간;정상결장화거결장정상단부함양성신경절세포화신경섬유.제시NO여선천성거결장발병궤리유관.
The nitric oxide synthase (NOS) distribution in the enteric nervous system (NANC inhibition system) was studied by NADPH-diphorase histochemistry method. It revealed completely lack of NOS activity in the neuro-plexus and in musculature of aganglionic segment, on the other hand in the ganglionic segment, NOS was abundant in pattern similar to normal colon. It suggests that NO has been involved in the pathophysiology of Hirschsprung disease.