CAJ | 학술논문

目的观察鸦胆子油乳注射液联合化疗治疗晚期非小细胞肺癌的临床效果.方法将56例晚期非小细胞肺癌患者完全随机分为2组,单纯化疗组给予单纯化疗(紫杉醇加顺铂),联合组给予鸦胆子油乳注射液联合化疗(方案同单纯化疗组),治疗2个周期后评价疗效.结果联合组和单纯化疗组患者有效率为分别39.3％(11/28)和35.7％(10/28),差异无统计学意义(P＞0.05),但临床受益率分别为82.2％(23/28)和71.4％(20/28),2组比较差异有统计学意义(P＜0.05),联合组患者生活质量明显高于单纯化疗组[46.4％( 13/28)比28.6％( 8/28),P＜0.05],白细胞下降率明显低于单纯化疗组[71.4％( 10/28)比85.7％(10/28),P＜0.05].结论鸦胆子油乳注射液联合化疗治疗晚期非小细胞肺癌,可以提高患者的临床受益率,同时明显提高患者的生活质量,减轻化疗的毒副反应.
목적 관찰아담자유유주사액연합화료치료만기비소세포폐암적림상효과.방법 장56례만기비소세포폐암환자완전수궤분위2조,단순화료조급여단순화료(자삼순가순박),연합조급여아담자유유주사액연합화료(방안동단순화료조),치료2개주기후평개료효.결과 연합조화단순화료조환자유효솔위분별39.3％(11/28)화35.7％(10/28),차이무통계학의의(P＞0.05),단림상수익솔분별위82.2％(23/28)화71.4％(20/28),2조비교차이유통계학의의(P＜0.05),연합조환자생활질량명현고우단순화료조[46.4％( 13/28)비28.6％( 8/28),P＜0.05],백세포하강솔명현저우단순화료조[71.4％( 10/28)비85.7％(10/28),P＜0.05].결론 아담자유유주사액연합화료치료만기비소세포폐암,가이제고환자적림상수익솔,동시명현제고환자적생활질량,감경화료적독부반응.
Objective To observe the clinical effects of Brucea Javanica oil emulsion combined with paclitaxol and cisplantin in treatment of advanced non-small cell lung cancer.Methods Fifty-six patients with advanced stage non-small cell lung cancer were randomized into group A (paclitaxol and cisplantin) and group B( Brucea Javanica oil emulsion combined with paclitaxol and cisplantin).Results The efficacy of two groups had no significances (P ＞0.05) (group A with 35.7％ and group B with 39.3％ ).But the clinical benefit rate had significance (group A with 71.4％ and group B with 82.2％ ) (P ＜ 0.05 ).Patients in group B had the better quality of life and less droop rate of white blood cell than those in group A ( P ＜ 0.05).Conclusion Using Brucea Javanica oil emulsion combined with paclitaxol and cisplantin can increase the clinical benefit rate,enhance the quality of life and relieve the side effects of chemotherapy in treatment of advanced non-small cell lung cancer.