CAJ | 학술논문

目的分析研究纤维支气管镜影像引导125I粒子植入治疗晚期中央型非小细胞肺癌的疗效.方法对确诊的66例晚期非小细胞肺癌患者制定系统放疗计划,通过纤维支气管镜影像引导植入放射性125I粒子,并行剂量学验证和定期复查随访.结果随访1年时,治疗组中完伞缓解15例,部分缓解36例,有效率77.3%,1年生存率80.3%;随访2年时,治疗组中完全缓解7例,部分缓解22例,稳定3例,无疾病进展1例,有效率90.6%,2年生存率是43.8%.无早晚期放射损伤发生.结论支气管镜引导植入125I粒子疗法能够较好地解除气道梗阻,对支气管肺癌具有明显的控制疗效.
목적 분석연구섬유지기관경영상인도125I입자식입치료만기중앙형비소세포폐암적료효.방법 대학진적66례만기비소세포폐암환자제정계통방료계화,통과섬유지기관경영상인도식입방사성125I입자,병행제량학험증화정기복사수방.결과 수방1년시,치료조중완산완해15례,부분완해36례,유효솔77.3%,1년생존솔80.3%;수방2년시,치료조중완전완해7례,부분완해22례,은정3례,무질병진전1례,유효솔90.6%,2년생존솔시43.8%.무조만기방사손상발생.결론 지기관경인도식입125I입자요법능구교호지해제기도경조,대지기관폐암구유명현적공제료효.
Objective To analyze therapeutic efficiency of 125 iodine brachytherapy seeds implantation guided by flexible fiber-optic bronchoscopy(FFB)image in terminal central non-small cell lung carcinoma (NSCLC).Methods Under therapy planning system (TPS) and guided by flexible fiber-optic bronchoscopy image,125 iodine seeds were implanted in 66 Confirmed terrainal cases with NSCLC and its posology Was validated and rechecked regularly.Remlts Complete remission (CR) was observed in 15 cases and partial remission (PR) in 36 cases during the first-year follow-up,with an overall efficiency rate (CR+PR) of 77.3 percent and one-year survival of 80.3 percent.Complete remission (CR) was observed in seven cases,partial remission (PR) in 22 cases,stable condition (SC) in three cases.and no progression was found during the second-year follow-up,respectively,with an overall efficiency rate (CR+PR) of 90.6 percent and two-year survival of 43.8 percent No radioactive damage were observed in the early and late stages of therapy.Conclusions Therapy with radioactive 125 iodine seeds implantation guided by flexible fiber-optic bronchoscopy image could relieve airway obstruction effectively in terminal lung cancer and control progression of bronchiogenic carcinoma.