无机化学学报
無機化學學報
무궤화학학보
JOURNAL OF INORGANIC CHEMISTRY
2001年
3期
427-430
,共4页
张永平%范丽岩%唐宁%谭民裕
張永平%範麗巖%唐寧%譚民裕
장영평%범려암%당저%담민유
2,2＇-二硫代二(N-氧化吡啶)稀土苦味酸盐合成表征抗肿瘤活性
2,2＇-二硫代二(N-氧化吡啶)稀土苦味痠鹽閤成錶徵抗腫瘤活性
2,2＇-이류대이(N-양화필정)희토고미산염합성표정항종류활성
Six rare earth picrate complexes with 2, 2＇-dithiobis(pyridine-N-oxide) (L) have been synthesized. The ligand L acts only as an N-oxide oxygen donor. The complexes were characterized by elemental analysis, and IR, and antitumor activity of [La(pie) 3L]·EtOH, [Eu(pic) 3L]·EtOH and [Er(pic)3L]·EtOH complexes were tested with L1210 and HL-60 cells, the preliminary results of in vitro test show that the inhibitory effects of the complexes were significantly greater than that of ligand. Eu (Ⅲ) complex to HL-60, La, Eu and Er complexes to L1210 all exhibit significant cytotoxicity and have potential prospect to be further developed.
