CAJ | 학술논문

目的探讨预缺血后短暂灌注(快速预缺血)对兔脑再缺血的影响.方法股动脉放血至平均动脉压35～40mmHg时,阻断双侧颈总动脉诱导脑缺血.20只兔随机分为对照组:脑缺血10min;实验组:脑缺血3min灌注30min后、脑再缺血10min,观察两组脑再缺血3、10d海马CA1区正常神经元密度.结果实验组脑缺血3d后海马CA1区正常神经元密度明显高于对照组,实验组脑缺血10d后海马CA1区正常神经元密度与对照组无明显差异.结论快速预缺血对兔脑再缺血具有保护作用,但仅出现在再灌注3d后而非10d后.
목적탐토예결혈후단잠관주(쾌속예결혈)대토뇌재결혈적영향.방법고동맥방혈지평균동맥압35～40mmHg시,조단쌍측경총동맥유도뇌결혈.20지토수궤분위대조조:뇌결혈10min;실험조:뇌결혈3min관주30min후、뇌재결혈10min,관찰량조뇌재결혈3、10d해마CA1구정상신경원밀도.결과실험조뇌결혈3d후해마CA1구정상신경원밀도명현고우대조조,실험조뇌결혈10d후해마CA1구정상신경원밀도여대조조무명현차이.결론쾌속예결혈대토뇌재결혈구유보호작용,단부출현재재관주3d후이비10d후.
[Objective] To explore the role of rapid ischemic preconditioning(IPC) protecting rabbits against ischemic neuronal damage following global cerebral ischemia. [Methods] Cerebral ischemia was produced by occlusion of both carotid arteries in combination with drawing blood to mean artery pressure(MAP) 35-40 mmHg. 20 rabbits were randomly divided into Control group: cerebral ischemia lasted 10min ,Experimental group: after 3-min IPC and 30 min of recovery, cerebral ischemia was induced and lasted 10min, neurons density in the hippocampal CA1region was examined and measured 3 days later or 10 days later. [Results] The neuronal density in CA1 region of hippocampus 3 days after cerebral ischemia in the experimental group was obviously higher than that in the control group. The neuronal density in CA1 region of hippocampus 10 days after cerebral ischemia had no obvious difference between experimental group and control group. [Conclusion] Rapid preconditioning protects rabbits against ischemic neuronal damage after 3 but 10 days of repeffusion following global cerebral ischemia.