中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2010年
2期
151-155
,共5页
贺海彪%顾振纶%蒋小岗%周文轩%郭次仪
賀海彪%顧振綸%蔣小崗%週文軒%郭次儀
하해표%고진륜%장소강%주문헌%곽차의
骨桥蛋白%肺纤维化%细胞外基质%成纤维细胞%肺泡上皮细胞%上皮间充质转变%信号通路
骨橋蛋白%肺纖維化%細胞外基質%成纖維細胞%肺泡上皮細胞%上皮間充質轉變%信號通路
골교단백%폐섬유화%세포외기질%성섬유세포%폐포상피세포%상피간충질전변%신호통로
osteopontin%pulmonary fibrosis%extracellular matrix%fibroblast%alveolar epithelial cell%epithelial-mesenchymal-transition%signal transduction
骨桥蛋白(osteopontin,OPN)是一种分泌型糖基化磷蛋白,广泛存在于各种组织和体液中,具有多种生物学活性,整合素α_v β_3是其主要受体.OPN主要参与细胞的增殖、分化、迁移及黏附.目前国内外对OPN的研究主要集中在骨吸收、血管生成、动脉粥样硬化、消化系统、泌尿系统、创面愈合、皮肤纤维化、肝纤维化、肾纤维化等方面,而在肺纤维化方面的研究报道较少,现将OPN与肺纤维化的关系作一综述.
骨橋蛋白(osteopontin,OPN)是一種分泌型糖基化燐蛋白,廣汎存在于各種組織和體液中,具有多種生物學活性,整閤素α_v β_3是其主要受體.OPN主要參與細胞的增殖、分化、遷移及黏附.目前國內外對OPN的研究主要集中在骨吸收、血管生成、動脈粥樣硬化、消化繫統、泌尿繫統、創麵愈閤、皮膚纖維化、肝纖維化、腎纖維化等方麵,而在肺纖維化方麵的研究報道較少,現將OPN與肺纖維化的關繫作一綜述.
골교단백(osteopontin,OPN)시일충분비형당기화린단백,엄범존재우각충조직화체액중,구유다충생물학활성,정합소α_v β_3시기주요수체.OPN주요삼여세포적증식、분화、천이급점부.목전국내외대OPN적연구주요집중재골흡수、혈관생성、동맥죽양경화、소화계통、비뇨계통、창면유합、피부섬유화、간섬유화、신섬유화등방면,이재폐섬유화방면적연구보도교소,현장OPN여폐섬유화적관계작일종술.
Osteopontin (OPN) is a secreted O-glycosylated phosphoprotein that exists in a variety of tissues and body fluids, with a variety of biological activity. Integrin α_vβ_3 is the main receptor. OPN mainly involves in cell proliferation, differentiation, migration and adhesion. The study of OPN at home and abroad mainly focuses on the bone resorption, angiogenesis, atherosclerosis, digestive system, urinary system, wound healing, skin fibrosis, liver fibrosis, kidney fibrosis, etc.But reports about OPN in pulmonary fibrosis are much less, now the relationships between OPN and pulmonary fibrosis are reviewed.
