合成化学
閤成化學
합성화학
CHINESE JOURNAL OF SYNTHETIC CHEMISTRY
2010年
1期
56-60
,共5页
于金兰%武钦佩%张青山%周智明
于金蘭%武欽珮%張青山%週智明
우금란%무흠패%장청산%주지명
1,2,3-三唑%叠氮基甲烷%端基炔%1,3-偶极环加成%合成
1,2,3-三唑%疊氮基甲烷%耑基炔%1,3-偶極環加成%閤成
1,2,3-삼서%첩담기갑완%단기결%1,3-우겁배가성%합성
1,2,3-triazole%methyl azide%terminal alkyne%1,3-dipolar cycloaddition%synthesis
在超声波辐射下,端基炔与叠氮基(3,3-二甲基-2,4-二氧戊环基)甲烷通过1,3-偶极环加成合成了1-(3,3-二甲基-2,4-二氧戊环基甲基)-4-芳基-1,2,3-三唑(5);5在酸性条件下脱保护得1-(2,3-二羟基丙基)-4-芳基-1,2,3-三唑(6),其结构经~1H NMR,~(13)C NMR,MS和元素分析表征.
在超聲波輻射下,耑基炔與疊氮基(3,3-二甲基-2,4-二氧戊環基)甲烷通過1,3-偶極環加成閤成瞭1-(3,3-二甲基-2,4-二氧戊環基甲基)-4-芳基-1,2,3-三唑(5);5在痠性條件下脫保護得1-(2,3-二羥基丙基)-4-芳基-1,2,3-三唑(6),其結構經~1H NMR,~(13)C NMR,MS和元素分析錶徵.
재초성파복사하,단기결여첩담기(3,3-이갑기-2,4-이양무배기)갑완통과1,3-우겁배가성합성료1-(3,3-이갑기-2,4-이양무배기갑기)-4-방기-1,2,3-삼서(5);5재산성조건하탈보호득1-(2,3-이간기병기)-4-방기-1,2,3-삼서(6),기결구경~1H NMR,~(13)C NMR,MS화원소분석표정.
1-(3,3-dimethyl-2,4-dioxolaneyl-methyl)-4-aryl -1,2,3-triazole(5) was synthesized by 1,3-dipolar cycloaddition of 3,3-dimethyl-2,4-dioxolaneyl-methyl azide and terminal alkyne under ultrasound irradiation for 20 min.The hydroxyl protection of 5 was removed in acidic solution to obtain 1-(2,3-dihydroxylpropyl)-4-aryl -1,2,3-triazole(6).The structures were characterized by ~1H NMR,~(13)C NMR,MS and elemental analysis.
