CAJ | 학술논문

[目的]探索长程抗焦虑抑郁药物治疗对稳定期慢性阻塞性肺疾病合并焦虑抑郁患者的治疗效果.[方法]采用医院焦虑和抑郁量表(Hospital Anxiety and Depression Scale,HADS)对门]诊COPD患者进行焦虑抑郁评分,分值大干10分并经过心理专科医生明确诊断者纳入研究,口服帕罗西汀Paroxetine(赛乐特),每天20 mg,于治疗后2周、8周、12周、16周进行HADS评分,比较治疗前后各项评分变化.[结果]29例合并焦虑抑郁的稳定期COPD患者完成实验,其中单独存在焦虑者9例,单独存在抑郁者5例,焦虑抑郁并存者15例.12周后患者的焦虑抑郁评分显著改善(P＜0.05),16周与12周评分差异无显著性(P＞0.05).[结论]至少12周的较长程帕罗西汀治疗可以改善慢性阻塞性肺疾病合并焦虑抑郁患者的精神症状,更长疗程的治疗并未获得更好的效果.
[목적]탐색장정항초필억욱약물치료대은정기만성조새성폐질병합병초필억욱환자적치료효과.[방법]채용의원초필화억욱량표(Hospital Anxiety and Depression Scale,HADS)대문]진COPD환자진행 초필억욱평분,분치대간10분병경과심리전과의생명학진단자납입연구,구복파라서정Paroxetine(새악특),매천20 mg,우치료후2주、8주、12주、16주진행HADS평분,비교치료전후각항평분변화.[결과]29례합병초필억욱적은정기COPD환자완성실험,기중단독존재초필자9례,단독존재억욱자5례,초필억욱병존자15례.12주후환자적초필억욱평분현저개선(P＜0.05),16주여12주평분차이무현저성(P＞0.05).[결론]지소12주적교장정파라서정치료가이개선만성조새성폐질병합병초필억욱환자적정신증상,경장료정적치료병미획득경호적효과.
[Objective]To evaluate the efficacy of antidepressant drug therapy in COPD-associated depression.[Methods]Outpatients were evaluated with moderate to severe,stable COPD completed Hospital Anxiety and Depression (HAD).Those with psychiatrist interviewed with high score s [HADS scale(anxiety or depression score) ＞ 10]were brought into study.Depressed or anxious COPD patients took a selective serotonin reuptake inhibitor,paroxetine 20 mg daily.All patients took paroxetine for 16 weeks.After 2,8,12 and 16 weeks,the HADS was repeated.[Results]Among the 41outpatients who entered the study,29 patients completed the study.Anxiety (only HADS anxiety score of ＞ 10) was indicated in 9 patienta and depression (only HADS depression score of ＞ 10) in 5,anxiety and depression (HADS anxiety+depression score all ＞ 10) in 15.12 weeks' treatment produced significant improvement in either anxiety or depression(P＜ 0.05).However,there were no significant differences in HADS scales at 12 weeks and 16 weeks(P＞ 0.05).[Conclusion]We conclude that at least 12 weeks of antidepressant drug therapy can produce significant improvement in either anxiety or depression in patients with COPD-associated depression.Longer period treatment could not acquire better curative effect.