中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
13期
5-8
,共4页
潘锋丰%钟远%章小燕%孙小康
潘鋒豐%鐘遠%章小燕%孫小康
반봉봉%종원%장소연%손소강
代谢综合征X%心室功能,左%左心室结构
代謝綜閤徵X%心室功能,左%左心室結構
대사종합정X%심실공능,좌%좌심실결구
Metabolic syndrome X%Ventrieular function,left%Left ventricular structure
目的 探讨代谢综合征(MS)患者左心室结构和功能的变化以及MS组分的聚集对左心室结构和功能的影响.方法 检测并比较27例MS患者(MS组)和69例非MS患者(非MS组)的左心室结构和功能,进一步根据MS定义中代谢异常组分的累加评分(0～4分)将所有患者分为5组.比较各组间左心室结构和功能变化.结果 MS组较非MS组舒张末期室间隔厚度(IVSD)、舒张末期左心室后壁厚度(LVPWD)、左心室质量指数(LVMI)均明显增加[(10.22±1.60)mm比(9.31±1.16)mm,(8.95±1.60)mm比(8.23±1.04)mm,(88.23±22.00)g/m~2比(77.56±14.12)g/m~2,P<0.05],等容舒张时间(IVRT)明显延长(P<0.05),二尖瓣口舒张早期血流充盈速度(E)和舒张晚期血流充盈速度(A)比值(E/A)明显降低(P<0.05);而左心室射血分数(LVEF)、左心室短轴缩短率(LVFS)均在正常范围内,且两组间比较差异无统计学意义.随着代谢异常组分分值的增加,IVSD、LVPWD、LVMI均有明显增加,IVRT有明显延长,E/A有明显下降.结论 MS患者较非MS患者有明显的左心室结构改变和左心室舒张功能的减退,且随着代谢异常组分的聚集,左心室结构变化和舒张功能的损害也有所增加.
目的 探討代謝綜閤徵(MS)患者左心室結構和功能的變化以及MS組分的聚集對左心室結構和功能的影響.方法 檢測併比較27例MS患者(MS組)和69例非MS患者(非MS組)的左心室結構和功能,進一步根據MS定義中代謝異常組分的纍加評分(0～4分)將所有患者分為5組.比較各組間左心室結構和功能變化.結果 MS組較非MS組舒張末期室間隔厚度(IVSD)、舒張末期左心室後壁厚度(LVPWD)、左心室質量指數(LVMI)均明顯增加[(10.22±1.60)mm比(9.31±1.16)mm,(8.95±1.60)mm比(8.23±1.04)mm,(88.23±22.00)g/m~2比(77.56±14.12)g/m~2,P<0.05],等容舒張時間(IVRT)明顯延長(P<0.05),二尖瓣口舒張早期血流充盈速度(E)和舒張晚期血流充盈速度(A)比值(E/A)明顯降低(P<0.05);而左心室射血分數(LVEF)、左心室短軸縮短率(LVFS)均在正常範圍內,且兩組間比較差異無統計學意義.隨著代謝異常組分分值的增加,IVSD、LVPWD、LVMI均有明顯增加,IVRT有明顯延長,E/A有明顯下降.結論 MS患者較非MS患者有明顯的左心室結構改變和左心室舒張功能的減退,且隨著代謝異常組分的聚集,左心室結構變化和舒張功能的損害也有所增加.
목적 탐토대사종합정(MS)환자좌심실결구화공능적변화이급MS조분적취집대좌심실결구화공능적영향.방법 검측병비교27례MS환자(MS조)화69례비MS환자(비MS조)적좌심실결구화공능,진일보근거MS정의중대사이상조분적루가평분(0～4분)장소유환자분위5조.비교각조간좌심실결구화공능변화.결과 MS조교비MS조서장말기실간격후도(IVSD)、서장말기좌심실후벽후도(LVPWD)、좌심실질량지수(LVMI)균명현증가[(10.22±1.60)mm비(9.31±1.16)mm,(8.95±1.60)mm비(8.23±1.04)mm,(88.23±22.00)g/m~2비(77.56±14.12)g/m~2,P<0.05],등용서장시간(IVRT)명현연장(P<0.05),이첨판구서장조기혈류충영속도(E)화서장만기혈류충영속도(A)비치(E/A)명현강저(P<0.05);이좌심실사혈분수(LVEF)、좌심실단축축단솔(LVFS)균재정상범위내,차량조간비교차이무통계학의의.수착대사이상조분분치적증가,IVSD、LVPWD、LVMI균유명현증가,IVRT유명현연장,E/A유명현하강.결론 MS환자교비MS환자유명현적좌심실결구개변화좌심실서장공능적감퇴,차수착대사이상조분적취집,좌심실결구변화화서장공능적손해야유소증가.
Objective To study the changes of left ventricular structure and function in patients of the metabolic syndrome(MS),and assess the effect of aggregations of MS components on left ventricular structure and function.Methods Left ventricular structure and function was detected and compared in 27cases with MS(MS group)and 69 cases without MS(non-MS group),and then all patients were categorized into 0 to 4 groups according to the number of MS components.Left ventricular structure and function were compared among groups.Results The interventricular septal thickness at end diastole(IVSD),left ventricular posterior wall thickness at enddiastole(LVPWD)and left ventricular mass index(LVMI)was increased in MS group than that in non-Ms group[(10.22±1.60)mm vs(9.31±1.16)mm,(8.95±1.60)mm vs(8.23±1.04)mm,(88.23±22.00)g/m~2 vs(77.56±14.12)g/m~2,P<0.05].Isovolumic relaxation time(IVRT)was found to be significantly higher and the ratio of peak velocity at early diastole to that at late diastole(E/A ratio)was significantly lower in MS group compared with that in non-MS group.However,left ventricular ejection fraction(LVEF)and left ventricular fractional shortening(LVFS)was detected to be within normal ranges in both groups and there was no significant difference between two groups.As the metabolic disorder score increased,IVSD,LVPWD,LVMI,IVRT were significantly increased and E/A ratio was significmatly decreased.Conclusions MS patients have significantly higher risk of impaired left ventricular structure and diastolic function than non-MS patients.The degree of metabolic disorder clustering is strongly related to the lesion of left ventricular structure and diastolic function.
