CAJ | 학술논문

目的观察腹腔热化疗治疗宫颈癌的临床疗效及不良反应.方法观察组40例接受多西他赛全身化疗+顺铂腹腔灌注联合腹部高频热疗,对照组40例接受多西他赛+顺铂全身化疗,观察其疗效及近期不良反应.结果观察组完全缓解率82.5％,有效率为92.5％；对照组分别为62.5％和75.0％.经过6个周期的化疗,观察组改善率85.0％,对照组改善率57.5％,两组差异有统计学意义(P＜0.05)；化疗过程中的主要毒副反应是胃肠道反应、白细胞减少、脱发,但两组差异无统计学意义(P＞0.05).结论多西他赛全身化疗联合顺铂腹腔热灌注化疗可显著提高宫颈癌的治疗效果,且不增加毒副作用.
목적 관찰복강열화료치료궁경암적림상료효급불량반응.방법 관찰조40례접수다서타새전신화료+순박복강관주연합복부고빈열료,대조조40례접수다서타새+순박전신화료,관찰기료효급근기불량반응.결과 관찰조완전완해솔82.5％,유효솔위92.5％；대조조분별위62.5％화75.0％.경과6개주기적화료,관찰조개선솔85.0％,대조조개선솔57.5％,량조차이유통계학의의(P＜0.05)；화료과정중적주요독부반응시위장도반응、백세포감소、탈발,단량조차이무통계학의의(P＞0.05).결론 다서타새전신화료연합순박복강열관주화료가현저제고궁경암적치료효과,차불증가독부작용.
Objective To observe the clinical efficacy and toxicity of intraperitoneal chemotherapy combined with intravenous chemotherapy in treatment of cervical cancer.Methods The experimental group of 40 patients received systemic chemotherapy of docetaxel and cisplatin combined abdominal intraperitoneal high-frequency hyperthermia in the control group,40 patients received docetaxel plus cisplatin chemotherapy,The efficacy and toxicity were observed.Results The complete remission rate of observotion group was 82.5％,significantly higher than 62.5％ in control group.Effective rate in observation group was 92.5％ and also significantly higher than 75.0％ in control gronp.After 6 cycles of chemotherapy,the improvement of the experimental group was 85.0％ higher than 57.5 ％ in control gronp.The differemles between the two groups was statistically significant(P ＜ 0.05); the main side effects during chemotherapy are gastrointestinal reactions,since the cells decreased,hair loss,the difference was not statistically significant(P ＞0.05).Conclusion The chemotherapy of docetaxel and cisplatin intraperitoneal chemotherapy can significantly improve the treatment of cervical cancer,without increasing side effects.