CAJ | 학술논문

载脂蛋白E(ApoE)是一种重要的血浆脂蛋白,由3种等位基因构成:E2、E3和E4.ApoE作为一种载脂蛋白,在脂质运输和代谢过程中发挥重要作用,而目前越来越多的研究表明:ApoE在免疫调节方面发挥重要作用,从而参与到多种疾病的发生发展中.近年来发现,ApoE及其基因多态性与高脂血症、动脉粥样硬化、Alzheimer病、神经系统病变及脓毒血症等人类疾患的发生发展有着密切关系.
재지단백E(ApoE)시일충중요적혈장지단백,유3충등위기인구성:E2、E3화E4.ApoE작위일충재지단백,재지질운수화대사과정중발휘중요작용,이목전월래월다적연구표명:ApoE재면역조절방면발휘중요작용,종이삼여도다충질병적발생발전중.근년래발현,ApoE급기기인다태성여고지혈증、동맥죽양경화、Alzheimer병、신경계통병변급농독혈증등인류질환적발생발전유착밀절관계.
Apolipoprotein E (ApoE), an important plasma lipoprotein, which has three isforms, E2,E3 and E4,plays an critical role in lipid transport and metabolism. Many studies showed ApoE also had immunoregulaory effect. It is suggested that ApoE may involved in the development of many diseases. ApoE and its gene polymorphism had a strong relationship with a variety diseases, such as hyperlipidemia, atherosclerosis,Alzheimer's diseases, diseaseses of Nervous system diseases and sepsis.