CAJ | 학술논문

目的观察低分子肝素用于妊娠中晚期羊水过少的治疗效果.方法 90例妊娠中晚期羊水过少患者随机分为两组,均每天静脉滴注复方氨基酸500 ml,5％葡萄糖注射液500 ml,分次饮水(汤、牛奶、水等)共1000 ml,每天左侧卧位休息不少于10 h,10d为1疗程.观察组加用低分子肝素(法安明)5000 U每天皮下注射1次.治疗后复查羊水指数,比较两组分娩方式、新生儿出生体质量、新生儿窒息、产后出血量等情况.结果治疗后观察组羊水指数、新生儿出生体质量明显高于对照组,剖宫产率、新生儿轻度窒息明显低于对照组(均P＜0.05).两组新生儿重度窒息、病死率及产妇产后出血量差异均无统计学意义(均P＞0.05).结论低分子肝素在妊娠中晚期羊水过少的治疗中可以显著增加羊水量、增加胎儿体质量,改善妊娠结局,且不增加出血风险,使用安全.
목적 관찰저분자간소용우임신중만기양수과소적치료효과.방법 90례임신중만기양수과소환자수궤분위량조,균매천정맥적주복방안기산500 ml,5％포도당주사액500 ml,분차음수(탕、우내、수등)공1000 ml,매천좌측와위휴식불소우10 h,10d위1료정.관찰조가용저분자간소(법안명)5000 U매천피하주사1차.치료후복사양수지수,비교량조분면방식、신생인출생체질량、신생인질식、산후출혈량등정황.결과 치료후관찰조양수지수、신생인출생체질량명현고우대조조,부궁산솔、신생인경도질식명현저우대조조(균P＜0.05).량조신생인중도질식、병사솔급산부산후출혈량차이균무통계학의의(균P＞0.05).결론 저분자간소재임신중만기양수과소적치료중가이현저증가양수량、증가태인체질량,개선임신결국,차불증가출혈풍험,사용안전.
Objective To detect the effect of LMWH on Oligohydramnios at mid and late trimester of pregnancy.Methods Patients were divided into two groups.Control group was given Compound amino acids 500ml,5％glucose solution 500ml by intravenous infusion and water 1000ml per oral per day,and rest in bed with left lateral position for 10 days.Test group was given the same treatments as control group,plus Flagmin 5000U by subcutaneous injection per day.Amniotic fluid index was retest after treatment.Delivery mode,newborn birth weight,neonatal asphyxia and amount of postpartum hemorrhage were compared between two groups.Results Amniotic fluid index and newborn birth weight of test group was significantly higher than control group( P ＜ 0.05).Cesarean section rate,mild neonatal asphyxia rate was significantly lower than control group( P ＜ 0.05).Severe neonatal asphyxia rate and amount of postpartum hemorrhage had no significant differences (all P＞0.05).Conclusion LMWH treatment could increase amniotic fluid volume and newborn birth weight on Oligohydramnios at mid and late trimester of pregnancy,improve pregnancy outcome,without increase of postpartum hemorrhage.