CAJ | 학술논문

目的比较体外循环热灌注化疗与腹腔化疗治疗恶性腹腔积液的疗效.方法 62例恶性腹腔积液患者完全随机分为观察组(30例)和对照组(32例).观察组采用TRL-2000体腔循环热化疗系统行腹腔热疗,腹腔内温度达41～43℃,给予顺铂60～80 mg、地塞米松10 mg注入腹腔,体腔循环持续60 min；对照组给予腹腔注入顺铂60～80 mg.2组均2次/周,治疗2周.观察2组的疗效及不良反应.结果观察组有效率90.0％( 27/30),卡氏评分改善80.0％( 24/30)；对照组有效率43.7％ (14/32),卡氏评分改善40.6％ (13/32),2组比较差异均有统计学意义(均P＜0.05).2组白细胞、肝肾功损伤及恶心呕吐、腹痛等不良反应发生率差异无统计学意义(P＞0.05).结论体腔循环灌注热化疗治疗恶性腹腔积液疗效好,患者生活质量提高较明显,患者可以耐受不良反应.
목적 비교체외순배열관주화료여복강화료치료악성복강적액적료효.방법 62례악성복강적액환자완전수궤분위관찰조(30례)화대조조(32례).관찰조채용TRL-2000체강순배열화료계통행복강열료,복강내온도체41～43℃,급여순박60～80 mg、지새미송10 mg주입복강,체강순배지속60 min；대조조급여복강주입순박60～80 mg.2조균2차/주,치료2주.관찰2조적료효급불량반응.결과 관찰조유효솔90.0％( 27/30),잡씨평분개선80.0％( 24/30)；대조조유효솔43.7％ (14/32),잡씨평분개선40.6％ (13/32),2조비교차이균유통계학의의(균P＜0.05).2조백세포、간신공손상급악심구토、복통등불량반응발생솔차이무통계학의의(P＞0.05).결론 체강순배관주열화료치료악성복강적액료효호,환자생활질량제고교명현,환자가이내수불량반응.
Objective To observe the efficacy of abdominal hyperthermic perfusion with intraperitoneal chemotherapy in patients with malignant seroperitoneum.Methods All 62 patients were divided into observation group (30 cases)and control group (32 cases)randomly.Observation group underwent abdominal hyperthermic perfusion and intraperitoneal chemotherapy with cisplatin. Control group was treated with intraperitoneal chemotherapy through peritoneal pipe. Both were given cisplatin 60 -80 mg twice a week.The responses of seroperitoneum and adverse events were observed.Results The total response rate of seroperitoneum in observation group was 90.0％ (27/30),the improvement rate of KPS was 80.0％ (24/30 ),while those in control group was 43.7％ (14/32)and 40.6％ (13/32 )respectively.The difference between the 2 groups were statistically significant difference (P＜0.05 ).The incidence rate of white blood cells,liver and kidney function damage and nausea and vomiting,abdominal pain and other adverse reactions in 2 groups had no statistically significant difference (P ＞ 0.05 ).Conclusion Abdominal hyperthermic perfusion combined with intraperitoneal chemotherapy have good efficacy and safety in treating malignant seroperitoneum.