CAJ | 학술논문

目的探讨高效抗逆转录病毒治疗(HAART)对中国南部地区艾滋病患者的免疫重建规律.方法收集近3年来300例患者的完整资料,按基线CD+4T细胞数分为A、B、C三组,观察基线及治疗1、3、6、12月末CD+4T淋巴细胞数、12月末血浆病毒载量(VL)、临床症状和毒副作用.结果抗病毒治疗12月末300例患者CD+4T淋巴细胞计数平均上升127个/l,以治疗3月后增长明显,3、12月末与基线CD+4T淋巴细胞计数比较差异有显著性(P＜0.05);12月末273例(91%)患者血浆病毒载量(VL)＜5 copies/ml,27例(9%)患者病毒载量(VL)＞50 copies/ml,高病毒载量A组16例,C组4例;A组与C组比较差异有显著性(P＜0.05);药物不良反应主要是外周神经炎(35.4%)、骨髓抑制(18.2%)、皮疹(15.2%)、肝功能损害(12.1%)、乳酸酸中毒(12.1%)和肾结石(6.1%).结论 HAART治疗对中国南部地区的艾滋病患者有效,能够实现免疫重建,但存在较多毒副作用.
목적 탐토고효항역전록병독치료(HAART)대중국남부지구애자병환자적면역중건규률.방법 수집근3년래300례환자적완정자료,안기선CD+4T세포수분위A、B、C삼조,관찰기선급치료1、3、6、12월말CD+4T림파세포수、12월말혈장병독재량(VL)、림상증상화독부작용.결과 항병독치료12월말300례환자CD+4T림파세포계수평균상승127개/l,이치료3월후증장명현,3、12월말여기선CD+4T림파세포계수비교차이유현저성(P＜0.05);12월말273례(91%)환자혈장병독재량(VL)＜5 copies/ml,27례(9%)환자병독재량(VL)＞50 copies/ml,고병독재량A조16례,C조4례;A조여C조비교차이유현저성(P＜0.05);약물불량반응주요시외주신경염(35.4%)、골수억제(18.2%)、피진(15.2%)、간공능손해(12.1%)、유산산중독(12.1%)화신결석(6.1%).결론 HAART치료대중국남부지구적애자병환자유효,능구실현면역중건,단존재교다독부작용.
Objective To observe the immunologic reconstitution in HIV/AIDS patients from the area of south China with highly active antiretroviral therapy(HAART).Methods 300 HIV/AIDS patients in recent three years were divided in to A、B、C three groups randomly according to baseline CD+4T cell counts.The counts of CD+4T cell were observed in patients at baseline and after 1,3,6 and 12 months of HAART,respectively,and plasma viral load (VL) was detected at the end 12 months,Clinical symptoms and drug side-effects were also observed.Results The counts of CD+4T were raised 127 cell/l in these 300 HIV/AIDS patients after 12 months with HAART.The rise in CD+4T cells was significant after HAART 3 months with.A significant increase in CD+4T cells was observed at 3 and 12 month after HAART compare to the baseline CD+4T cells counts (t=16.8、t=11.95,P＜0.05).After 12 months of treatment,plasma viral load was less than 50 copies/ml in 273 (91%) HIV/AIDS patients while viral load more than 50 copies/ml found in 27 cases.These were 16 cases with high viral load in group A and 4 cases in group C,Difference of the two groups was significant(χ2=4.37 P＜0.05).The main side-effects in HAART were neuropathy(35.4%),bone marrow depression(18.2%),rash(15.2%),liver function injury(12.1%),lactic acidosis(12.1%) and kidney calculi(6.1%).Conclusion Highly active antiretroviral therapy was effective in HIV/AIDS patients in the area of south China,and immunologic reconstitution achieved by highly active antiretroviral therapy with some side-effects observed.