生物信息学
生物信息學
생물신식학
BIOINFORMATICS
2012年
2期
130-135
,共6页
杨梅茜%王淑栋%张媛媛%孟大志
楊梅茜%王淑棟%張媛媛%孟大誌
양매천%왕숙동%장원원%맹대지
系统生物学%基因网络%表型网络%基因表达谱%互信息
繫統生物學%基因網絡%錶型網絡%基因錶達譜%互信息
계통생물학%기인망락%표형망락%기인표체보%호신식
Systems biology%Gene network%Phenotype network%Gene expression profiles%Mutual information
近来,人们发现从疾病相关基因中寻找关键基因对疾病的诊断和治疗很重要.癌相关基因的网络是根据正常和患病的胶质瘤组织的基因表达谱建立.根据建立的基因网络和CIPHER方法,不同阈值下的正常和患病的胶质瘤表型网络被建立.根据已知的疾病和表型间的关联,另一组正常和患病的胶质瘤表型网络被建立.将两种方法建立的相应的表型网络进行比较,匹配度最大时对应的阈值及基因和表型网络被确定.在此基础上,通过打分方法得到了7个关键基因:DMBT1,ERBB2,NF2,PDGFB,AR,ARAF和TP53.文献查询发现其中5个基因与胶质瘤的形成和发展密切相关.剩下两个基因中的ARAF也间接地参与胶质瘤形成.因此,这两个基因可能在胶质瘤的形成中起重要作用.这一预测仍需要实验验证.
近來,人們髮現從疾病相關基因中尋找關鍵基因對疾病的診斷和治療很重要.癌相關基因的網絡是根據正常和患病的膠質瘤組織的基因錶達譜建立.根據建立的基因網絡和CIPHER方法,不同閾值下的正常和患病的膠質瘤錶型網絡被建立.根據已知的疾病和錶型間的關聯,另一組正常和患病的膠質瘤錶型網絡被建立.將兩種方法建立的相應的錶型網絡進行比較,匹配度最大時對應的閾值及基因和錶型網絡被確定.在此基礎上,通過打分方法得到瞭7箇關鍵基因:DMBT1,ERBB2,NF2,PDGFB,AR,ARAF和TP53.文獻查詢髮現其中5箇基因與膠質瘤的形成和髮展密切相關.剩下兩箇基因中的ARAF也間接地參與膠質瘤形成.因此,這兩箇基因可能在膠質瘤的形成中起重要作用.這一預測仍需要實驗驗證.
근래,인문발현종질병상관기인중심조관건기인대질병적진단화치료흔중요.암상관기인적망락시근거정상화환병적효질류조직적기인표체보건립.근거건립적기인망락화CIPHER방법,불동역치하적정상화환병적효질류표형망락피건립.근거이지적질병화표형간적관련,령일조정상화환병적효질류표형망락피건립.장량충방법건립적상응적표형망락진행비교,필배도최대시대응적역치급기인화표형망락피학정.재차기출상,통과타분방법득도료7개관건기인:DMBT1,ERBB2,NF2,PDGFB,AR,ARAF화TP53.문헌사순발현기중5개기인여효질류적형성화발전밀절상관.잉하량개기인중적ARAF야간접지삼여효질류형성.인차,저량개기인가능재효질류적형성중기중요작용.저일예측잉수요실험험증.
It is believed that finding key genes from disease-related genes is important for diagnosis and treatment of dis ease.In this work,networks of cancer-related genes are constructed based on their expression data in glioma tissues with and without cancer.Based on this,networks of glioma-related phenotypes for corresponding tissues are constructed using the method of CIPHER.Another group of networks of corresponding phenotypes for glioma tissues with and without cancer are constructed based on the known correlations between diseases and phenotypes.When the matching degree between a phenotype network built by CIPHER under a certain threshold and that constructed by the known correlations reaches maximum for glioma tissues with and without cancer,the corresponding gene and phenotype networks under the threshold are obtained.Based on these determined gene and phenotype networks,seven key genes DMBTI,ERBB2,NF2,PDGFB,AR,ARAF and TP53 are given by scoring method.Our literature review shows that five of these seven genes are closely related to the formation and development of glioma,leaving AR and ARAF open.Furthermore,ARAF participates indirectly in the formation of glioma.Therefore,we predict the two open genes may play important roles in the formation of glioma.These predictions call for empirical studies.