CAJ | 학술논문

目的观察唑来膦酸联合放疗治疗骨转移癌的疗效.方法 71例骨转移癌患者随机分为观察组40例和对照组31例,观察组静脉滴注唑来膦酸4 mg加局部放疗;对照组采用单纯放疗.结果观察组和对照组治疗结束时止痛有效率分别为90%和83.9%,差异无统计学意义(P>0.05);治疗结束后3个月后疼痛缓解情况:观察组和对照组的止痛有效率分别为87.5%和67.7%,差异有统计学意义(χ2=4.09,P=0.043).未发现严重放射和药物不良反应.结论唑来膦酸联合放疗治疗骨转移癌疼痛疗效优于单纯放疗,止痛维持时间较长.
목적 관찰서래련산연합방료치료골전이암적료효.방법 71례골전이암환자수궤분위관찰조40례화대조조31례,관찰조정맥적주서래련산4 mg가국부방료;대조조채용단순방료.결과 관찰조화대조조치료결속시지통유효솔분별위90%화83.9%,차이무통계학의의(P>0.05);치료결속후3개월후동통완해정황:관찰조화대조조적지통유효솔분별위87.5%화67.7%,차이유통계학의의(χ2=4.09,P=0.043).미발현엄중방사화약물불량반응.결론 서래련산연합방료치료골전이암동통료효우우단순방료,지통유지시간교장.
Objective To evaluate the efficacy of zoledronic acid combined with radiotherapy for bone meta-static cancer. Methods 71 cases with bone metastatic cancer were randomly divided into observation group (40 ca-ses) and control group (31 cases). The observation group was treated with zoledronic acid, 4 mg intravenously and local radiotherapy. The control group was treatd by radiotherapy alone. Results Pain relief was noted in 90% pa-tients in the observation group and 83.9% in the control group, respectively. The statistical difference was not signif-icant(P > 0.05). After the treatment had finished 3 months pain alleviation situation:Pain relief was noted in 87.5% patients in the observation group and 67.7% in the control group, respectively. The difference between the two groups was significant(χ2 =4.09, P =0.043). No serious radiotherapy and serious adverse drug reactions was found. Conclusion Zoledronic acid combined with radiotherapy was superior to radiotherapy alone for metastatic cancer bone pain relief, analgesic effect maintain a longer time.