CAJ | 학술논문

雄激素即男性激素对男性性别的分化和发育起重要作用.但雄激素的作用远不止于此.动物实验表明,雄激素对大脑性别差异的发育,以及对维持两性行为和认知的差异都非常重要.现已了解,决定人性别的基本要素与其它哺乳动物相似.但是,性激素对两性神经系统、两性行为、认知差异的影响,以及其与哺乳动物的相互关系还不甚了解, 是一门吸引众多科学家研究的新兴领域.本综述通过对雄激素受体突变引起的雄激素不敏感综合症和5α-还原酶-2突变引起的5α-还原酶-2缺乏症的探讨,深入阐述了雄激素在男性性别、行为和认知中所起的作用;同时强调了先天与后天因素相互作用的重要性.
웅격소즉남성격소대남성성별적분화화발육기중요작용.단웅격소적작용원불지우차.동물실험표명,웅격소대대뇌성별차이적발육,이급대유지량성행위화인지적차이도비상중요.현이료해,결정인성별적기본요소여기타포유동물상사.단시,성격소대량성신경계통、량성행위、인지차이적영향,이급기여포유동물적상호관계환불심료해, 시일문흡인음다과학가연구적신흥영역.본종술통과대웅격소수체돌변인기적웅격소불민감종합증화5α-환원매-2돌변인기적5α-환원매-2결핍증적탐토,심입천술료웅격소재남성성별、행위화인지중소기적작용;동시강조료선천여후천인소상호작용적중요성.
Androgens, the male sex hormones, play an essential role in male sexual differentiation and development. However, the influence of these sex hormones extends beyond their roles in sexual differentiation and development. In many animal species, sex hormones have been shown to be essential for sexual differentiation of the brain during development and for maintaining sexually dimorphic behavior throughout life. The principals of sex determination in humans have been demonstrated to be similar to other mammals. However, the hormonal influence on sexual dimorphic differences in the nervous system in humans, sex differences in behaviors, and its correlations with those of other mammals is still an emerging field. In this review, the roles of androgens in gender and cognitive function are discussed with the emphasis on subjects with androgen action defects including complete androgen insensitivity due to androgen receptor mutations and 5α-reductase-2 deficiency syndromes due to 5α-reductase-2 gene mutations. The issue of the complex interaction of nature versus nurture is addressed.