CAJ | 학술논문

建立了HPLC法测定马鞭草苷在大鼠血浆、人血浆和牛血清白蛋白中的蛋白结合率,并计算不同种属血浆蛋白的相关参数.结果显示,体外马鞭草苷与大鼠血浆、人血浆和牛血清白蛋白结合率低,且与血药浓度无显著相关性.
건립료HPLC법측정마편초감재대서혈장、인혈장화우혈청백단백중적단백결합솔,병계산불동충속혈장단백적상관삼수.결과현시,체외마편초감여대서혈장、인혈장화우혈청백단백결합솔저,차여혈약농도무현저상관성.
An HPLC method was established for the determination of the protein binding rates of verbenalin in rat plasma, human plasma and bovine serum albumin (BSA). The related parameters of verbenalin to different genera plasma proteins were also calculated. The binding rates of verbenalin in rat plasma, human plasma and BSA were low in vitro. Moreover, the binding rates were not proportionally dependent on plasma concentration of verbenalin.