中华口腔医学杂志
中華口腔醫學雜誌
중화구강의학잡지
Chinese Journal of Stomatology
2012年
8期
490-494
,共5页
张春波%孙新华%侯旭%闫阔
張春波%孫新華%侯旭%閆闊
장춘파%손신화%후욱%염활
磷酸钙类%酪蛋白类%牙釉质%牙再矿化
燐痠鈣類%酪蛋白類%牙釉質%牙再礦化
린산개류%락단백류%아유질%아재광화
Calcium phosphates%Caseins%Dental enamel%Tooth remineralization
目的 评价酪蛋白磷酸肽-非结晶型磷酸钙(casein phosphopeptide-amorphous calcium phosphate,CPP-ACP)与几种临床常用的含氟制剂抑制牙釉质脱矿的作用,为正畸临床预防牙釉质脱矿提供依据.方法 将70颗离体牙分为7组,每组10颗,即A组:CPP-ACP组；B组:CPP-ACP+含氟漱口水组；C组:含氟漱口水组；D组:含氟玻璃离子牙体保护剂组；E组:含氟树脂粘接剂组；F组:氟保护漆组；G组:空白对照组.将7组样本按三餐进食时间放人人工致龋液中,每次10 min,前6组分别于样本颊面釉质表面涂布CPP-ACP、CPP-ACP和含氟漱口水、含氟漱口水、含氟玻璃离子牙体保护剂、含氟树脂粘接剂、氟保护漆,空白对照组不处理,7组样本其余时间均浸泡于人工唾液中.于实验1、2、3个月用原子力显微镜检测.结果 实验1个月D组釉质表面粗糙度[(114±1) nm]显著低于G组[(172±9) nm] (P ＜0.05)；实验2和3个月各组釉质表面粗糙度与G组差异均有统计学意义(P＜0.05)；B组粗糙度2和3个月为(87±9)和(27±6) nm,显著低于其他各组(P＜0.05)；C组2和3个月粗糙度分别为(145±8)和(126±7)nm,显著高于D、E、F组(P＜0.05).结论 CPP-ACP与含氟制剂在人工致龋环境中均有抑制牙釉质脱矿的作用,CPP-ACP与含氟制剂联合应用效果更佳；含氟固体(D、E、F组)比含氟液体(C组)抑制牙釉质脱矿作用效果更好.
目的 評價酪蛋白燐痠肽-非結晶型燐痠鈣(casein phosphopeptide-amorphous calcium phosphate,CPP-ACP)與幾種臨床常用的含氟製劑抑製牙釉質脫礦的作用,為正畸臨床預防牙釉質脫礦提供依據.方法 將70顆離體牙分為7組,每組10顆,即A組:CPP-ACP組；B組:CPP-ACP+含氟漱口水組；C組:含氟漱口水組；D組:含氟玻璃離子牙體保護劑組；E組:含氟樹脂粘接劑組；F組:氟保護漆組；G組:空白對照組.將7組樣本按三餐進食時間放人人工緻齲液中,每次10 min,前6組分彆于樣本頰麵釉質錶麵塗佈CPP-ACP、CPP-ACP和含氟漱口水、含氟漱口水、含氟玻璃離子牙體保護劑、含氟樹脂粘接劑、氟保護漆,空白對照組不處理,7組樣本其餘時間均浸泡于人工唾液中.于實驗1、2、3箇月用原子力顯微鏡檢測.結果 實驗1箇月D組釉質錶麵粗糙度[(114±1) nm]顯著低于G組[(172±9) nm] (P ＜0.05)；實驗2和3箇月各組釉質錶麵粗糙度與G組差異均有統計學意義(P＜0.05)；B組粗糙度2和3箇月為(87±9)和(27±6) nm,顯著低于其他各組(P＜0.05)；C組2和3箇月粗糙度分彆為(145±8)和(126±7)nm,顯著高于D、E、F組(P＜0.05).結論 CPP-ACP與含氟製劑在人工緻齲環境中均有抑製牙釉質脫礦的作用,CPP-ACP與含氟製劑聯閤應用效果更佳；含氟固體(D、E、F組)比含氟液體(C組)抑製牙釉質脫礦作用效果更好.
목적 평개락단백린산태-비결정형린산개(casein phosphopeptide-amorphous calcium phosphate,CPP-ACP)여궤충림상상용적함불제제억제아유질탈광적작용,위정기림상예방아유질탈광제공의거.방법 장70과리체아분위7조,매조10과,즉A조:CPP-ACP조；B조:CPP-ACP+함불수구수조；C조:함불수구수조；D조:함불파리리자아체보호제조；E조:함불수지점접제조；F조:불보호칠조；G조:공백대조조.장7조양본안삼찬진식시간방인인공치우액중,매차10 min,전6조분별우양본협면유질표면도포CPP-ACP、CPP-ACP화함불수구수、함불수구수、함불파리리자아체보호제、함불수지점접제、불보호칠,공백대조조불처리,7조양본기여시간균침포우인공타액중.우실험1、2、3개월용원자력현미경검측.결과 실험1개월D조유질표면조조도[(114±1) nm]현저저우G조[(172±9) nm] (P ＜0.05)；실험2화3개월각조유질표면조조도여G조차이균유통계학의의(P＜0.05)；B조조조도2화3개월위(87±9)화(27±6) nm,현저저우기타각조(P＜0.05)；C조2화3개월조조도분별위(145±8)화(126±7)nm,현저고우D、E、F조(P＜0.05).결론 CPP-ACP여함불제제재인공치우배경중균유억제아유질탈광적작용,CPP-ACP여함불제제연합응용효과경가；함불고체(D、E、F조)비함불액체(C조)억제아유질탈광작용효과경호.
Objective To evaluate casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and several fluoride products in inhibiting enamel demineralization.Methods Seventy healthy premolars extracted before orthodontic treatment were divided into seven groups (A: CPP-ACP; B:CPP-ACP + fluoride mouth rinses; C:fluoride mouth rinses; D:fluoride glass ionomer protection; E:fluoride resin binder; F:fluoride varnish; G:control group).There were ten samples in each group. The teeth were dipped into an artificial caries solution ten minutes at a time,then applied separately with CPP-ACP,CPP-ACP + fluoride mouth rinses,fluoride mouth rinses,fluoride glass ionomer protection,fluoride resin binder and fluoride varnish on labial enamel.The samples were dipped into an artificial saliva solution ( 37 ℃ ).Then all samples were examined with atomic force microscope ( AFM ) at the end of first,second and third monthes.Results At the end of the first month,surface roughness in group D [ ( 114 ±1 ) nm] was significantly lower than that in group G[ ( 172 ±9) nm].At the end of the second month and the third month,significant difference was found in surface roughness between group G and the rest of groups (P ＜ 0.05 ) ; between group B and the rest of groups ; and between group C and groups ( D,E and F).Conclusions CPP-ACP and fluoride could both inhibit enamel demineralization in vitro. Solid fluoride (groups D,E and F) had better results than liquid fluoride (group C).
