中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2012年
9期
683-687
,共5页
癌,肝细胞%着色性干皮病基因D组%多态性,基因%Meta分析
癌,肝細胞%著色性榦皮病基因D組%多態性,基因%Meta分析
암,간세포%착색성간피병기인D조%다태성,기인%Meta분석
Carcinoma,hepatocellular%Xeroderma pigmentosum group D%Gene polymorphism%Meta-analysis
目的 探讨DNA切除修复基因XPD基因多态性在中国人群原发性肝癌中的遗传易感性. 方法 检索中外数据库,获得有关XPD基因多态性与肝癌发病风险的病例对照研究资料进行Meta分析,得到合并的优势比(OR)和95％可信区间(95％CI). 结果 共纳入XPD基因多态位点相关文献6篇,累计病例3424例,对照3636例；在XPD基因多态位点751和312位点等位基因的OR (95％CI)分别为1.25 (0.70～ 2.24)和0.85 (0.58～ 1.25);在XPD基因多态位点751,与野生基因型Lys/Lys相比,(Lys/Gln+Gln/Gln)合并的OR(95％CI)为1.31(0.71 ～ 2.42)；在XPD基因多态位点312位点,与野生基因型Asp/Asp相比,(Asp/Asn+Asn/Asn)合并的OR值(95％CI)为1.19 (0.73～ 1.95). 结论 XPD多态性遗传位点751和312不是中国人群原发性肝癌发病的风险因素.
目的 探討DNA切除脩複基因XPD基因多態性在中國人群原髮性肝癌中的遺傳易感性. 方法 檢索中外數據庫,穫得有關XPD基因多態性與肝癌髮病風險的病例對照研究資料進行Meta分析,得到閤併的優勢比(OR)和95％可信區間(95％CI). 結果 共納入XPD基因多態位點相關文獻6篇,纍計病例3424例,對照3636例；在XPD基因多態位點751和312位點等位基因的OR (95％CI)分彆為1.25 (0.70～ 2.24)和0.85 (0.58～ 1.25);在XPD基因多態位點751,與野生基因型Lys/Lys相比,(Lys/Gln+Gln/Gln)閤併的OR(95％CI)為1.31(0.71 ～ 2.42)；在XPD基因多態位點312位點,與野生基因型Asp/Asp相比,(Asp/Asn+Asn/Asn)閤併的OR值(95％CI)為1.19 (0.73～ 1.95). 結論 XPD多態性遺傳位點751和312不是中國人群原髮性肝癌髮病的風險因素.
목적 탐토DNA절제수복기인XPD기인다태성재중국인군원발성간암중적유전역감성. 방법 검색중외수거고,획득유관XPD기인다태성여간암발병풍험적병례대조연구자료진행Meta분석,득도합병적우세비(OR)화95％가신구간(95％CI). 결과 공납입XPD기인다태위점상관문헌6편,루계병례3424례,대조3636례；재XPD기인다태위점751화312위점등위기인적OR (95％CI)분별위1.25 (0.70～ 2.24)화0.85 (0.58～ 1.25);재XPD기인다태위점751,여야생기인형Lys/Lys상비,(Lys/Gln+Gln/Gln)합병적OR(95％CI)위1.31(0.71 ～ 2.42)；재XPD기인다태위점312위점,여야생기인형Asp/Asp상비,(Asp/Asn+Asn/Asn)합병적OR치(95％CI)위1.19 (0.73～ 1.95). 결론 XPD다태성유전위점751화312불시중국인군원발성간암발병적풍험인소.
Objective To explore the association between polymorphisms in the DNA repair gene,xeroderma pigmentosum group D (XPD),and development of hepatocellular carcinoma (HCC) in the Chinese population by performing a systematic review of the previously published clinical data.Methods A comprehensive literature search of the BIOSIS Previews and PubMed databases was carried out to identify all case-control studies of XPD polymorphisms and HCC risk.Meta-analysis was conducted to calculate the pooled odds ratios (ORs) with 95％ confidence intervals (CIs) of developing HCC for carriers of the various XPD polymorphisms.Results Six case-control studies were selected for this meta-analysis,and comprised a total of 3424 HCC cases and 3636 controls.The pooled ORs (95％ CIs) of XPD codon 751 and 312 allelomorphs were 1.25 (0.70 ～ 2.24) and 0.85 (0.58 ～ 1.25),respectively.Compared with the XPD wild-type homozygote Lys/Lys genotype of codon 751,the pooled OR (95％ CI) of Lys/Gln + Gln/Gln genotypes for HCC risk was 1.31 (0.71 ～ 2.42).Compared with the XPD wild-type homozygote Asp/Asp genotype of codon 312,the pooled OR (95％ CI) ofAsp/Asn + Asn/Asn genotypes for HCC risk was 1.19 (0.73 ～ 1.95).Conclusion Polymorphisms in the XPD codons 751 and 312 are not associated with HCC risk in the Chinese population.
