国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2011年
4期
262-267
,共6页
MiR-21%肿瘤%靶基因%合成与调控%临床意义
MiR-21%腫瘤%靶基因%閤成與調控%臨床意義
MiR-21%종류%파기인%합성여조공%림상의의
MiR-21%Tumor%Target gene%Biosynthesis and Regulation%Clinical significance
MieroRNA(miRNA)是一类内源性具有调控功能的小分子非编码RNA,长度18～23 nt,主要在转录后水平调节基因表达.最近,大量研究表明,miR-21可作为原癌基因在多种肿瘤中高表达并参与细胞的增生、分化、凋亡等过程,在肿瘤的发生发展中具有重要作用.本文从miR-21的自身合成与表达调控、靶基因的验证及临床意义等方面作一综述,以便为将来的研究及临床应用提供可参考的重要资料.
MieroRNA(miRNA)是一類內源性具有調控功能的小分子非編碼RNA,長度18～23 nt,主要在轉錄後水平調節基因錶達.最近,大量研究錶明,miR-21可作為原癌基因在多種腫瘤中高錶達併參與細胞的增生、分化、凋亡等過程,在腫瘤的髮生髮展中具有重要作用.本文從miR-21的自身閤成與錶達調控、靶基因的驗證及臨床意義等方麵作一綜述,以便為將來的研究及臨床應用提供可參攷的重要資料.
MieroRNA(miRNA)시일류내원성구유조공공능적소분자비편마RNA,장도18～23 nt,주요재전록후수평조절기인표체.최근,대량연구표명,miR-21가작위원암기인재다충종류중고표체병삼여세포적증생、분화、조망등과정,재종류적발생발전중구유중요작용.본문종miR-21적자신합성여표체조공、파기인적험증급림상의의등방면작일종술,이편위장래적연구급림상응용제공가삼고적중요자료.
MicroRNA are endogenous non-coding small RNA composed of approximately 18 - 23 nucleotides, mainly participating in post-transcription gene regulation. More and more data show that miR-21 is over-expressed in many human cancer cells and it was involved in cell differentiation, proliferation and apoptosis, closely related to tumorigenesis and the development of carcinoma as oncogene. Here, we will make a review about miR-21' s target gene, biosynthesis and regulation and clinical significance in order to provide a valued data for the future study and clinical application.
